Seminoma pathophysiology: Difference between revisions
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==Immunohistochemistry== | ==Immunohistochemistry== | ||
Seminoma is demonstrated by positivity to [[tumor marker]]s, such as:<ref name=IHCofseminoma1>IHC for seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016</ref> | Seminoma is demonstrated by positivity to [[tumor marker]]s, such as:<ref name=IHCofseminoma1>IHC for seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016</ref> | ||
*[[OCT3]] | |||
*[[OCT4]] | *[[OCT4]] | ||
*[[CD117]] | *[[CD117]] | ||
*[[D2-40]] | *[[D2-40]] | ||
*[[CD117]] | *[[CD117]] | ||
==References== | ==References== | ||
Revision as of 15:50, 3 March 2016
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Seminoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Seminoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Seminoma pathophysiology |
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Risk calculators and risk factors for Seminoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Gross Pathology
On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.[1]
Microscopic Pathology
- On microscopic pathology, seminoma is characterized by:[2]
- Cells with fried egg appearance - key feature
- Clear cytoplasm
- Central nucleus, with prominent nucleolus. Nucleus may have "corners", i.e. it is not round.
- Lymphocytes - interspersed (common)
- Syncytiotrophoblasts, present in 10-20% of seminoma
- Large, irregular, vesicular nuclei
- Eosinophilic vacuolated cytoplasm (contains hCG)
- Florid granulomatous reaction
- Approximately 24% of Stage I seminomas have lymphovascular invasion for stage I (Tx, N0, M0).[2]
- Intertubular seminoma may not form a discrete mass and mimic a benign testis.[2]
Gallery
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![Microscopic image of seminoma demonstrating fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus) and lymphocytic infiltrate.[2]](/images/1/1c/800px-Seminoma_high_mag.jpg)
Microscopic image of seminoma demonstrating fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus) and lymphocytic infiltrate.[2]
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![Very high magnification micrograph of a seminoma with syncytiotrophoblasts on H&E stain. Syncytiotrophoblasts are seen in approximately 10-20% of seminomas. They may be associated with an elevated serum beta-hCG.[2]](/images/7/7e/800px-Seminoma_with_syncytiotrophoblasts_-_very_high_mag.jpg)
Very high magnification micrograph of a seminoma with syncytiotrophoblasts on H&E stain. Syncytiotrophoblasts are seen in approximately 10-20% of seminomas. They may be associated with an elevated serum beta-hCG.[2]
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![Histopathological image of metastatic seminoma in the inguinal lymph node on hematoxylin & eosin stain.[2]](/images/f/f6/Testicular_seminoma_%281%29_nodal_metastasis.jpg)
Histopathological image of metastatic seminoma in the inguinal lymph node on hematoxylin & eosin stain.[2]
![Microscopic image of seminoma demonstrating fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus) and lymphocytic infiltrate.[2]](/index.php/File:800px-Seminoma_high_mag.jpg)
![Very high magnification micrograph of a seminoma with syncytiotrophoblasts on H&E stain. Syncytiotrophoblasts are seen in approximately 10-20% of seminomas. They may be associated with an elevated serum beta-hCG.[2]](/index.php/File:800px-Seminoma_with_syncytiotrophoblasts_-_very_high_mag.jpg)
![Histopathological image of metastatic seminoma in the inguinal lymph node on hematoxylin & eosin stain.[2]](/index.php/File:Testicular_seminoma_(1)_nodal_metastasis.jpg)
Immunohistochemistry
Seminoma is demonstrated by positivity to tumor markers, such as:[3]
References
- ↑ Pathology of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiipaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on February 29, 2016
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016
- ↑ IHC for seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016