Mast cell tumor laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Following laboratory tests may be considered for the diagnosis of mast cell tumor:<ref name="FerranteScavone2015">{{cite journal|last1=Ferrante|first1=Giuliana|last2=Scavone|first2=Valeria|last3=Muscia|first3=Maria|last4=Adrignola|first4=Emilia|last5=Corsello|first5=Giovanni|last6=Passalacqua|first6=Giovanni|last7=La Grutta|first7=Stefania|title=The care pathway for children with urticaria, angioedema, mastocytosis|journal=World Allergy Organization Journal|volume=8|issue=1|year=2015|pages=5|issn=1939-4551|doi=10.1186/s40413-014-0052-x}}</ref> | Following laboratory tests may be considered for the diagnosis of mast cell tumor:<ref name="FerranteScavone2015">{{cite journal|last1=Ferrante|first1=Giuliana|last2=Scavone|first2=Valeria|last3=Muscia|first3=Maria|last4=Adrignola|first4=Emilia|last5=Corsello|first5=Giovanni|last6=Passalacqua|first6=Giovanni|last7=La Grutta|first7=Stefania|title=The care pathway for children with urticaria, angioedema, mastocytosis|journal=World Allergy Organization Journal|volume=8|issue=1|year=2015|pages=5|issn=1939-4551|doi=10.1186/s40413-014-0052-x}}</ref><ref name="OzdemirDagdelen2010">{{cite journal|last1=Ozdemir|first1=Didem|last2=Dagdelen|first2=Selcuk|last3=Erbas|first3=Tomris|last4=Agbaht|first4=Kemal|last5=Serefhanoglu|first5=Songul|last6=Aksu|first6=Salih|last7=Ersoy-Evans|first7=Sibel|title=Hypotension, Syncope, and Fever in Systemic Mastocytosis without Skin Infiltration and Rapid Response to Corticosteroid and Cyclosporin: A Case Report|journal=Case Reports in Medicine|volume=2010|year=2010|pages=1–4|issn=1687-9627|doi=10.1155/2010/782595}}</ref> | ||
*[[Complete blood count]] | *[[Complete blood count]] | ||
:*[[Eosinophilia]] | :*[[Eosinophilia]] | ||
:*[[Thrombocytopenia]] | :*[[Thrombocytopenia]] | ||
*[[Tryptase]] levels | *[[Tryptase]] levels | ||
:*Tryptase which is stored almost exclusively within the secretory granules of mast cells is the most widely used marker of mastocytosis. | :*Tryptase which is stored almost exclusively within the secretory granules of mast cells is the most widely used marker of mastocytosis. | ||
:*In healthy individuals, serum tryptase levels range between <1 and 15 ng/mL; however, mast cell activation causes increased tryptase levels. | :*In healthy individuals, serum tryptase levels range between <1 and 15 ng/mL; however, mast cell activation causes increased tryptase levels. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
Following laboratory tests may be considered for the diagnosis of mast cell tumor:[1][2]
- Tryptase levels
- Tryptase which is stored almost exclusively within the secretory granules of mast cells is the most widely used marker of mastocytosis.
- In healthy individuals, serum tryptase levels range between <1 and 15 ng/mL; however, mast cell activation causes increased tryptase levels.
- Additionally, tryptase levels in SM are assumed to correlate closely with the cumulative mast cell burden and multiorgan involvement
- Plasma and urinary histamine
- Chronically elevated plasma and urinary histamine levels and its metabolite N-methylhistamine
- Elevated in a blood sample obtained immediately after attack
- Prostaglandin - D2
- Elevated
References
- ↑ Ferrante, Giuliana; Scavone, Valeria; Muscia, Maria; Adrignola, Emilia; Corsello, Giovanni; Passalacqua, Giovanni; La Grutta, Stefania (2015). "The care pathway for children with urticaria, angioedema, mastocytosis". World Allergy Organization Journal. 8 (1): 5. doi:10.1186/s40413-014-0052-x. ISSN 1939-4551.
- ↑ Ozdemir, Didem; Dagdelen, Selcuk; Erbas, Tomris; Agbaht, Kemal; Serefhanoglu, Songul; Aksu, Salih; Ersoy-Evans, Sibel (2010). "Hypotension, Syncope, and Fever in Systemic Mastocytosis without Skin Infiltration and Rapid Response to Corticosteroid and Cyclosporin: A Case Report". Case Reports in Medicine. 2010: 1–4. doi:10.1155/2010/782595. ISSN 1687-9627.