Donovanosis pathophysiology: Difference between revisions

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Revision as of 15:50, 4 March 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2]; Nate Michalak, B.A.

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Donovan bodies (K. granulomatis) are seen within phagosomes or in the cytoplasm of monocytes or histocytes.
Morphology of Donovan bodies:

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 ==Pathophysiology==
 ===Transmission===
 ===Pathogenesis===
 ====Virulence Factors====
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 ==Microscopic Pathology==
-The proper clinical designation for donovanosis is ''granuloma inguinale''.<ref>Murray P. et al. (2005), ''Medical Microbiology, fifth ed.'', Elsevier Mosby, p. 336.</ref>  [[Granuloma]] is a nodular type of inflammatory reaction, and inguinale refers to the [[inguinal]] region, which is commonly involved in this infection. The disease is commonly known as ''donovanosis'', after the Donovan Bodies which are a diagnostic sign. Discovered by a researcher named Donovan, these intracellular inclusions represent bacteria that have been engulfed by scavenger cells called mononuclear phagocytes or [[histiocytes]].
+*Donovan bodies (''K. granulomatis'') are seen within phagosomes or in the cytoplasm of monocytes or histocytes.
+*Morphology of Donovan bodies:
+:*Pleomorphic ranging from coccus to bacillus
+:*1-2 X 0.5-0.7 μm
+:*May or may not be capsulated
+:*Non-motile
+*[[Epidermis]] of lesion borders show a degree of [[hyperplasia]].
+*A dense infiltrate of plasma cells is seen in the [[dermis]].
 ==References==
-<references/>
+{{reflist|2}}
 [[Category:Sexually transmitted infections]]
 [[Category:Bacterial diseases]]