Nodal marginal zone lymphoma: Difference between revisions
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* [[Lymphadenopathy|Peripheral lymphadenopathy]] | * [[Lymphadenopathy|Peripheral lymphadenopathy]] | ||
=== Laboratory Findings === | ===Laboratory Findings === | ||
Laboratory tests for nodal marginal zone lymphoma include: | |||
* [[Complete blood count]] (CBC) | |||
* Blood chemistry studies | |||
* Cytogenetic analysis | |||
* [[Flow cytometry]] | |||
=== | * [[Immunohistochemistry]] | ||
* [[Immunophenotyping]] | |||
===Biopsy=== | |||
Lymph node or bone marrow biopsy is diagnostic of nodal marginal zone lymphoma. | |||
====CT ==== | ====CT ==== | ||
[[CT]] scan may be helpful in the diagnosis of nodal marginal zone lymphoma. | |||
==== MRI ==== | ==== MRI ==== | ||
[[MRI]] scan may be helpful in the diagnosis of nodal marginal zone lymphoma. | |||
==== Other Imaging Findings ==== | ==== Other Imaging Findings ==== | ||
[[PET]] scan may be helpful in the diagnosis of nodal marginal zone lymphoma. | |||
=== Other Diagnostic Studies === | === Other Diagnostic Studies === | ||
Revision as of 16:45, 4 March 2016
For patient information, click Insert page name here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Synonyms and keywords:: NMZL; Nodal marginal zone B cell lymphoma; Monocytoid B-cell lymphoma; Nodal monocytoid B-cell lymphoma
Overview
Pathophysiology
Genetics
Associated Conditions
Gross Pathology
Microscopic Pathology
Causes
There are no established causes for nodal marginal zone lymphoma.
Differentiating type page name here from other Diseases
Epidemiology and Demographics
Age
The incidence of nodal marginal zone lymphoma increases with age; the median age at diagnosis is 60 years.
Gender
Females are more commonly affected with nodal marginal zone lymphoma than males.
Risk Factors
There are no established risk factors for nodal marginal zone lymphoma.
Screening
According to the the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine screening for nodal marginal zone lymphoma.
Natural History, Complications and Prognosis
Nodal marginal zone lymphoma is often slow growing (indolent). However, it can change (transform) into a more aggressive large cell lymphoma. Nodal marginal zone lymphomas behave slightly more aggressively than MALT lymphomas.
Diagnosis
Symptoms
Symptoms of the nodal marginal zone lymphoma include:
- Fever
- Weight loss
- Night sweats
- Painless swelling in the neck, axilla, groin, thorax, and abdomen
Physical Examination
Vitals
- Fever is often present
HEENT
Thorax
- Thoracic masses suggestive of central lymphadenopathy
Abdomen
- Abdominal masses suggestive of central lymphadenopathy
Extremities
Laboratory Findings
Laboratory tests for nodal marginal zone lymphoma include:
- Complete blood count (CBC)
- Blood chemistry studies
- Cytogenetic analysis
- Flow cytometry
- Immunohistochemistry
- Immunophenotyping
Biopsy
Lymph node or bone marrow biopsy is diagnostic of nodal marginal zone lymphoma.
CT
CT scan may be helpful in the diagnosis of nodal marginal zone lymphoma.
MRI
MRI scan may be helpful in the diagnosis of nodal marginal zone lymphoma.
Other Imaging Findings
PET scan may be helpful in the diagnosis of nodal marginal zone lymphoma.
Other Diagnostic Studies
Treatment
Medical Therapy
| Therapy | Description |
|---|---|
| Watchful waiting |
|
| Chemotherapy |
|
| Biological therapy |
|
| Radiation therapy |
|
| Stem cell transplant |
|