Mast cell tumor laboratory findings: Difference between revisions
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{{familytree/start |summary=Skin lesions or suggestive clinical}} | {{familytree/start |summary=Skin lesions or suggestive clinical}} | ||
{{familytree |boxstyle=background: #DCDCDC; | | | | | | | | | | A01 |A01=<div style="width: | {{familytree |boxstyle=background: #DCDCDC; | | | | | | | | | | A01 |A01=<div style="width: 12em; padding:0.2em;">'''Skin lesions or suggestive clinical features'''</div>}} | ||
{{familytree| | | | | | | | | | |!| }} | {{familytree| | | | | | | | | | |!| }} | ||
{{familytree |boxstyle=background: #DCDCDC; | | | | | | | | | | A01 |A01=<div style="width: 12em; padding:0.2em;">'''Serum Tryptase''' | {{familytree |boxstyle=background: #DCDCDC; | | | | | | | | | | A01 |A01=<div style="width: 12em; padding:0.2em;">'''Serum Tryptase''' | ||
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{{familytree |boxstyle=background: #DCDCDC; | | | | | | B01 | | | | | | B02 |B01=<div style="width: 9em; padding:0.2em;">'''Normal complete blood count''' | {{familytree |boxstyle=background: #DCDCDC; | | | | | | B01 | | | | | | B02 |B01=<div style="width: 9em; padding:0.2em;">'''Normal complete blood count''' | ||
'''Serum tryptase ≤ 100ng/ml''' | '''Serum tryptase ≤ 100ng/ml''' | ||
</div>|B02=<div style="width: 9em; padding:0.2em;">'''Abnormal complete blood cell count''' '''Serum tryptase > 100 ng/ml'''</div>}} | </div>|B02=<div style="width: 9em; padding:0.2em;">'''Abnormal complete blood cell count''' | ||
'''Serum tryptase > 100 ng/ml'''</div>}} | |||
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{{familytree |boxstyle=background: #DCDCDC; | | | | | | C01 | | | | | |C02 |C01=<div style="width: 9em; padding:0.2em;">'''Cutaneous mastocytosis''' | {{familytree |boxstyle=background: #DCDCDC; | | | | | | C01 | | | | | |C02 |C01=<div style="width: 9em; padding:0.2em;">'''Cutaneous mastocytosis''' | ||
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</div>|B02=<div style="width: 9em; padding:0.2em;">'''Positive findings:''' '''Systemic mastocytosis'''</div>}} | </div>|B02=<div style="width: 9em; padding:0.2em;">'''Positive findings:''' '''Systemic mastocytosis'''</div>}} | ||
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Revision as of 20:10, 4 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
Skin lesions or suggestive clinical features | |||||||||||||||||||||||||||||||||||||
Serum Tryptase
Complete blood count Complete metabolic panel | |||||||||||||||||||||||||||||||||||||
Normal complete blood count
Serum tryptase ≤ 100ng/ml | Abnormal complete blood cell count
Serum tryptase > 100 ng/ml | ||||||||||||||||||||||||||||||||||||
Cutaneous mastocytosis
| Bone marrow: biopsy and aspiration
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Negative findings:
Other diagnosis | Positive findings: Systemic mastocytosis | ||||||||||||||||||||||||||||||||||||
The diagnosis of systemic mastocytosis is established by demonstrating mast cell infiltration in an involved tissue, particularly the bone marrow, using special staining techniques or flow cytometry, but the measurement of serum tryptase is a good screening test, since almost all patients with systemic mastocytosis have serum tryptase levels exceeding 20 ng/mL.[1]
- Tryptase which is stored almost exclusively within the secretory granules of mast cells is the most widely used marker of mastocytosis.
- In healthy individuals, serum tryptase levels range between <1 and 15 ng/mL; however, mast cell activation causes increased tryptase levels.
- Additionally, tryptase levels in SM are assumed to correlate closely with the cumulative mast cell burden and multiorgan involvement
- Plasma and urinary histamine
- Chronically elevated plasma and urinary histamine levels and its metabolite N-methylhistamine
- Elevated in a blood sample obtained immediately after attack
References
- ↑ Koenig, Martial; Morel, Jérôme; Reynaud, Jacqueline; Varvat, Cécile; Cathébras, Pascal (2008). "An unusual cause of spontaneous bleeding in the intensive care unit – mastocytosis: a case report". Cases Journal. 1 (1): 100. doi:10.1186/1757-1626-1-100. ISSN 1757-1626.
- ↑ Ozdemir, Didem; Dagdelen, Selcuk; Erbas, Tomris; Agbaht, Kemal; Serefhanoglu, Songul; Aksu, Salih; Ersoy-Evans, Sibel (2010). "Hypotension, Syncope, and Fever in Systemic Mastocytosis without Skin Infiltration and Rapid Response to Corticosteroid and Cyclosporin: A Case Report". Case Reports in Medicine. 2010: 1–4. doi:10.1155/2010/782595. ISSN 1687-9627.