Seminoma pathophysiology: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
Line 4: Line 4:


==Overview==
==Overview==
On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.<ref name=pathologyoftesticularseminoma1>Pathology of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiipaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on February 29, 2016</ref> On microscopic pathology, seminoma is characterized by the cells with fried egg appearance with clear cytoplasm and central nucleus with prominent nucleolus, with interspersed lymphocytes and [[syncytiotrophoblast]]s.<ref name=pathologyofseminoma1>Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016</ref> Approximately 24% of Stage I seminomas have ''lymphovascular invasion'' for stage I (Tx, N0, M0). Intertubular seminoma may not form a discrete mass and mimic a benign testis.<ref name=pathologyofseminoma1>Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016</ref> Seminoma  is demonstrated by positivity to [[tumor marker]]s, such as [[OCT4]], [[CD117]], D2-40, and [[CD117]].<ref name=IHCofseminoma1>IHC for seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016</ref>
On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.<ref name=pathologyoftesticularseminoma1>Pathology of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiipaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on February 29, 2016</ref> On microscopic pathology, seminoma is characterized by the cells with fried egg appearance with clear cytoplasm and central nucleus with prominent nucleolus, with interspersed lymphocytes and [[syncytiotrophoblast]]s.<ref name=pathologyofseminoma1>Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016</ref> Approximately 24% of Stage I seminomas have lymphovascular invasion for stage I (Tx, N0, M0). Intertubular seminoma may not form a discrete mass and mimic a benign testis.<ref name=pathologyofseminoma1>Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016</ref> Seminoma  is demonstrated by positivity to [[tumor marker]]s, such as [[OCT4]], [[CD117]], D2-40, and [[CD117]].<ref name=IHCofseminoma1>IHC for seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016</ref>


==Gross Pathology==   
==Gross Pathology==   

Revision as of 14:37, 7 March 2016

Seminoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Seminoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

TNM
Stage Grouping

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Treatment - Stage I
Treatment - Stage II
Treatment - Stage III
Treatment - Recurrent

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Seminoma pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Seminoma pathophysiology

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Seminoma pathophysiology

CDC on Seminoma pathophysiology

Seminoma pathophysiology in the news

Blogs on Seminoma pathophysiology

Directions to Hospitals Treating Seminoma

Risk calculators and risk factors for Seminoma pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.[1] On microscopic pathology, seminoma is characterized by the cells with fried egg appearance with clear cytoplasm and central nucleus with prominent nucleolus, with interspersed lymphocytes and syncytiotrophoblasts.[2] Approximately 24% of Stage I seminomas have lymphovascular invasion for stage I (Tx, N0, M0). Intertubular seminoma may not form a discrete mass and mimic a benign testis.[2] Seminoma is demonstrated by positivity to tumor markers, such as OCT4, CD117, D2-40, and CD117.[3]

Gross Pathology

On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.[1]

Gallery

  • Gross specimen of testicle demonstrating a solid, white/tan mass.[2]

    Gross specimen of testicle demonstrating a solid, white/tan mass.[2]

Microscopic Pathology

  • On microscopic pathology, seminoma is characterized by:[2]
  • Cells with fried egg appearance - key feature
  • Clear cytoplasm
  • Central nucleus, with prominent nucleolus. Nucleus may have "corners", i.e. it is not round.
  • Large, irregular, vesicular nuclei
  • Eosinophilic vacuolated cytoplasm (contains hCG)
  • Florid granulomatous reaction
  • Approximately 24% of Stage I seminomas have lymphovascular invasion for stage I (Tx, N0, M0).[2]
  • Intertubular seminoma may not form a discrete mass and mimic a benign testis.[2]

Gallery

  • Microscopic image of seminoma demonstrating fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus) and lymphocytic infiltrate.[2]

    Microscopic image of seminoma demonstrating fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus) and lymphocytic infiltrate.[2]

  • Very high magnification micrograph of a seminoma with syncytiotrophoblasts on H&E stain. Syncytiotrophoblasts are seen in approximately 10-20% of seminomas. They may be associated with an elevated serum beta-hCG.[2]

    Very high magnification micrograph of a seminoma with syncytiotrophoblasts on H&E stain. Syncytiotrophoblasts are seen in approximately 10-20% of seminomas. They may be associated with an elevated serum beta-hCG.[2]

  • Histopathological image of metastatic seminoma in the inguinal lymph node on hematoxylin & eosin stain.[2]

    Histopathological image of metastatic seminoma in the inguinal lymph node on hematoxylin & eosin stain.[2]

Immunohistochemistry

Seminoma is demonstrated by positivity to tumor markers, such as:[3]

References

  1. ↑ 1.0 1.1 Pathology of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiipaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on February 29, 2016
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016
  3. ↑ 3.0 3.1 IHC for seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Seminoma_pathophysiology&oldid=1222715"