Mast cell tumor overview: Difference between revisions
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==Differentiating Mast Cell Tumor from other Diseases== | ==Differentiating Mast Cell Tumor from other Diseases== | ||
Mast cell tumor must be differentiated from other diseases that cause [[flushing]],such as: [[phaeochromocytoma]] and [[carcinoid syndrome]].<ref name=Patient>Mastocytosis and mast cell disorders.Patient info.http://patient.info/doctor/mastocytosis-and-mast-cell-disorders#ref-20 accessed on March 7th, 2016</ref> Mast cell tumor must be differentiated from other diseases that cause elevated serum tryptase levels and cytopenia, such as: [[myelodysplastic syndrome]], [[primary myelofibrosis]], [[essential thrombocythemia]], and [[chronic eosinophilic leukemia]]. | Mast cell tumor must be differentiated from other diseases that cause [[flushing]],such as: [[phaeochromocytoma]] and [[carcinoid syndrome]].<ref name=Patient>Mastocytosis and mast cell disorders.Patient info.http://patient.info/doctor/mastocytosis-and-mast-cell-disorders#ref-20 accessed on March 7th, 2016</ref> Mast cell tumor must be differentiated from other diseases that cause elevated serum tryptase levels and cytopenia, such as: [[myelodysplastic syndrome]], [[primary myelofibrosis]], [[essential thrombocythemia]], and [[chronic eosinophilic leukemia]]. | ||
Revision as of 20:31, 7 March 2016
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Overview
A mast cell tumor is a type of tumor consisting of mast cells that is found in many species of animals. It refers to an accumulation or nodule of mast cells that resembles a tumor. Mastocytosis is a rare and heterogeneous disease characterized by the presence of excessive numbers of mast cells in various organs, mainly the skin and the bone marrow that manifests with an unusually broad spectrum of clinical and morphological appearances.
Classification
Based on the affected organ(s), mast cell tumor may be classified into either cutaneous mastocytosis or systemic mastocytosis. Mast cell tumor may be classified into seven subtypes based on WHO classification system.[1]
Pathophysiology
Mast cell tumor arises from the mast cell, which is a type of white blood cell involved in the inflammatory process. The progression to mast cell tumor usually involves the uncontrolled stimulation of the receptor for stem cell factor following mutation of C-kit cell surface receptor.[2] On microscopic histopathological analysis, mast cells in the superficial and mid dermis that are lymphocyte like with dense granular cytoplasm which tend to be more abundant around blood vessels is characteristic finding of mast cell tumor.[3]
Causes
There are no established causes for mast cell tumor.
Differentiating Mast Cell Tumor from other Diseases
Mast cell tumor must be differentiated from other diseases that cause flushing,such as: phaeochromocytoma and carcinoid syndrome.[4] Mast cell tumor must be differentiated from other diseases that cause elevated serum tryptase levels and cytopenia, such as: myelodysplastic syndrome, primary myelofibrosis, essential thrombocythemia, and chronic eosinophilic leukemia.
References
- ↑ Patnaik MM, Rindos M, Kouides PA, Tefferi A, Pardanani A (2007). "Systemic mastocytosis: a concise clinical and laboratory review". Arch Pathol Lab Med. 131 (5): 784–91. doi:10.1043/1543-2165(2007)131[784:SMACCA]2.0.CO;2. PMID 17488167.
- ↑ Adolf, Stefanie; Millonig, Gunda; Seitz, Helmut Karl; Reiter, Andreas; Schirmacher, Peter; Longerich, Thomas; Mueller, Sebastian (2012). "Systemic Mastocytosis: A Rare Case of Increased Liver Stiffness". Case Reports in Hepatology. 2012: 1–6. doi:10.1155/2012/728172. ISSN 2090-6587.
- ↑ Mastocytosis. Libre Pathology. http://librepathology.org/wiki/Mastocytosis accessed on March 1st, 2016
- ↑ Mastocytosis and mast cell disorders.Patient info.http://patient.info/doctor/mastocytosis-and-mast-cell-disorders#ref-20 accessed on March 7th, 2016