Myelofibrosis laboratory tests: Difference between revisions
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*[[megakaryocytes|Dysplastic megakaryocytes]] | *[[megakaryocytes|Dysplastic megakaryocytes]] | ||
===JAK2 Mutation Analysis Testing=== | |||
*''[[JAK 2]]'' mutation on Val 617 Phe locus in 50% | |||
* Raised levels of [[lactate dehydrogenase]] | * Raised levels of [[lactate dehydrogenase]] | ||
* Raised neutrophil alkaline phosphatase score | * Raised neutrophil alkaline phosphatase score | ||
Revision as of 16:35, 8 March 2016
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Myelofibrosis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Myelofibrosis laboratory tests On the Web |
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American Roentgen Ray Society Images of Myelofibrosis laboratory tests |
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Risk calculators and risk factors for Myelofibrosis laboratory tests |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Laboratory Tests
Laboratory findings consistent with the diagnosis of myelofibrosis include:[1]
Complete Blood Count
Peripheral Blood Smear
- Normochromic normocytic anemia
- Red cell poikilocytosis on blood film (tear-drop shaped RBCs)
- Nucleated red blood cells
- Presence of nucleated red blood cells suggests that immature cells are being released into the bloodstream in response to a very high demand for the bone marrow to produce new red blood cells.
JAK2 Mutation Analysis Testing
- JAK 2 mutation on Val 617 Phe locus in 50%
- Raised levels of lactate dehydrogenase
- Raised neutrophil alkaline phosphatase score
TB testing
The patient with the myelofibrosis should be tested for Tuberculosis even if the patient doesn't manifest the symptoms of TB. There is strong evidence of myelofibrois improvement with the antituberculous treatment.
References
- ↑ Diagnosis of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 8, 2016