Giant cell tumor of bone overview: Difference between revisions
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* [[Osteosarcoma]] | * [[Osteosarcoma]] | ||
* Giant cell reparative granuloma | * Giant cell reparative granuloma | ||
* [[Brown tumor]] of hyperparathyroidism. | * [[Brown tumor]] of hyperparathyroidism. | ||
==History and Symptoms== | |||
* Patients usually present with pain and limited [[range of motion]] caused by tumor's proximity to the joint space. | |||
* There may be [[swelling]] as well, if the tumor has been growing for a long time. | |||
* Some patients may be asymptomatic until they develop a pathologic [[fracture]] at the site of the tumor. | |||
==References== | ==References== | ||
Revision as of 15:43, 9 March 2016
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Giant cell tumor of bone Microchapters |
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Differentiating Giant cell tumor of bone from other Diseases |
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Giant cell tumor of bone overview On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Giant cell tumor of the bone is a relatively uncommon tumor. It is characterized by the presence of multinucleated giant cells (osteoclast-like cells). These tumors are generally benign. In most patients, the tumors are slow to develop, but may recur locally in as many as 50% of cases. Metastasis to the lungs may occur.
Prevalence
Giant cell tumor of the bone accounts for 4-5% of primary bone tumors and 18.2% of benign bone tumors [1]. Giant cell tumors are mostly benign, however 5-10% of patients may have a malignant tumor.
Differential Diagnosis
A number of tumors have giant cells, but are not true benign giant cell tumors. These include
- Aneurysmal bone cyst
- Chondroblastoma
- Simple bone cyst
- Osteoid osteoma
- Osteoblastoma
- Osteosarcoma
- Giant cell reparative granuloma
- Brown tumor of hyperparathyroidism.
History and Symptoms
- Patients usually present with pain and limited range of motion caused by tumor's proximity to the joint space.
- There may be swelling as well, if the tumor has been growing for a long time.
- Some patients may be asymptomatic until they develop a pathologic fracture at the site of the tumor.
References
- ↑ Gamberi G, Serra M, Ragazzini P, Magagnoli G, Pazzaglia L, Ponticelli F, Ferrari C, Zanasi M, Bertoni F, Picci P, Benassi MS (2003). "Identification of markers of possible prognostic value in 57 giant cell tumors of bone". Oncology Reports. 10 (2): 351–6. PMID 12579271. Retrieved 2012-01-18.