Myelofibrosis natural history, complications and prognosis: Difference between revisions
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*[[Infections]] | *[[Infections]] | ||
*[[Bleeding]] | *[[Bleeding]] | ||
*[[Blood clots]] | *[[Blood clots|Thrombohemorrhagic events]] | ||
*[[Hepatic failure]] | *[[Hepatic failure]] | ||
*[[Heart failure]] | |||
*[[Gout]] | *[[Gout]] | ||
*[[Bone marrow failure]] | *[[Bone marrow failure|Progressive marrow failure]] | ||
*[[Hypertrophic osteoarthropathy]] | *[[Hypertrophic osteoarthropathy]] | ||
Revision as of 15:06, 10 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Natural History
Myelofibrosis has a very indolent course.[1]
Complications
Common complications of myelofibrosis include:[2][3][4]
- Acute myelogenous leukemia
- Infections
- Bleeding
- Thrombohemorrhagic events
- Hepatic failure
- Heart failure
- Gout
- Progressive marrow failure
- Hypertrophic osteoarthropathy
Prognosis
- Prognosis of myelofibrosis is poor, with slow progression and death usually within 2-3 years.[5]
- The median survival for myelofibrosis is 3.5 years to 5.5 years, but patients younger than 55 years have a median survival of 11 years.[6] The major causes of death include:[6]
- Progressive marrow failure
- Transformation to acute nonlymphoblastic leukemia
- Infection
- Thrombohemorrhagic events
- Heart failure
- Portal hypertension
References
- ↑ Diagnosis of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 8, 2016
- ↑ Complications of myelofibrosis. US National Library of Medicine 2016. https://www.nlm.nih.gov/medlineplus/ency/article/000531.htm. Accessed on March 7, 2016
- ↑ Signs and symptoms of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 7, 2016
- ↑ Kelle, Bayram; Yıldız, Fatih; Paydas, Semra; Bagır, Emine Kılıc; Ergin, Melek; Kozanoglu, Erkan (2015). "Coexistence of hypertrophic osteoarthropathy and myelofibrosis". Revista Brasileira de Reumatologia (English Edition). doi:10.1016/j.rbre.2014.11.004. ISSN 2255-5021.
- ↑ Treatment and prognosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 8, 2016
- ↑ 6.0 6.1 Disease overview of primary myelofibrosis. National cancer institute 2016. http://www.cancer.gov/types/myeloproliferative/hp/chronic-treatment-pdq#section/_9. Accessed on March 10, 2016