Myelofibrosis natural history, complications and prognosis: Difference between revisions
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==Prognosis== | ==Prognosis== | ||
*Prognosis | *Prognosis is generally poor and the median survival for myelofibrosis is 3.5 years to 5.5 years, but patients younger than 55 years have a median survival of 11 years.<ref name=diseaseoverviewmf1>Disease overview of primary myelofibrosis. National cancer institute 2016. http://www.cancer.gov/types/myeloproliferative/hp/chronic-treatment-pdq#section/_9. Accessed on March 10, 2016</ref> | ||
*Poor prognostic factors for myelofibrosis include:<ref name=diseaseoverviewmf1>Disease overview of primary myelofibrosis. National cancer institute 2016. http://www.cancer.gov/types/myeloproliferative/hp/chronic-treatment-pdq#section/_9. Accessed on March 10, 2016</ref> | |||
*Poor prognostic factors for myelofibrosis include: | |||
:*Age 65 years or older | :*Age 65 years or older | ||
:*[[Anemia]] (hemoglobin <10 g/dL). | :*[[Anemia]] (hemoglobin <10 g/dL). | ||
:*Constitutional symptoms | :*Constitutional symptoms ([[fever]], [[night sweats]], or [[weight loss]]) | ||
:*[[Leukocytosis]] (white blood cell count >25 × 10<sup>9</sup>/L). | :*[[Leukocytosis]] (white blood cell count >25 × 10<sup>9</sup>/L). | ||
:*Circulating blasts of at least 1%. | :*Circulating blasts of at least 1%. | ||
Revision as of 15:11, 10 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Natural History
Myelofibrosis has a very indolent course.[1]
Complications
Common complications of myelofibrosis include:[2][3][4][5]
- Acute myelogenous leukemia
- Infections
- Bleeding
- Thrombohemorrhagic events
- Hepatic failure
- Heart failure
- Gout
- Progressive marrow failure
- Hypertrophic osteoarthropathy
Prognosis
- Prognosis is generally poor and the median survival for myelofibrosis is 3.5 years to 5.5 years, but patients younger than 55 years have a median survival of 11 years.[5]
- Poor prognostic factors for myelofibrosis include:[5]
- Age 65 years or older
- Anemia (hemoglobin <10 g/dL).
- Constitutional symptoms (fever, night sweats, or weight loss)
- Leukocytosis (white blood cell count >25 × 109/L).
- Circulating blasts of at least 1%.
References
- ↑ Diagnosis of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 8, 2016
- ↑ Complications of myelofibrosis. US National Library of Medicine 2016. https://www.nlm.nih.gov/medlineplus/ency/article/000531.htm. Accessed on March 7, 2016
- ↑ Signs and symptoms of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 7, 2016
- ↑ Kelle, Bayram; Yıldız, Fatih; Paydas, Semra; Bagır, Emine Kılıc; Ergin, Melek; Kozanoglu, Erkan (2015). "Coexistence of hypertrophic osteoarthropathy and myelofibrosis". Revista Brasileira de Reumatologia (English Edition). doi:10.1016/j.rbre.2014.11.004. ISSN 2255-5021.
- ↑ 5.0 5.1 5.2 Disease overview of primary myelofibrosis. National cancer institute 2016. http://www.cancer.gov/types/myeloproliferative/hp/chronic-treatment-pdq#section/_9. Accessed on March 10, 2016