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'''For patient information, click [[Meigs syndrome (patient information)|here]]'''
{{SI}}                                                                     
{{CMG}} {{AE}} {{MV}}
{{SK}} Demons Meigs syndrome; Meigs-Cass syndrome; Meigs-Salmon syndrome
==Overview==


{{Infobox_Disease |
'''Meigs syndrome''' '''(also known as "Demons Meigs syndrome")''' is defined as the triad of ascites, pleural effusion, and benign ovarian tumor (fibroma, Brenner tumour and occasionally granulosa cell tumour). Meigs syndrome was first discovered by Otto von Spiegelberg, a German gynecologist, in 1866.<ref name="pmid20896800">{{cite journal |vauthors=Tait L |title=On the occurrence of Pleural Effusion in association with Disease of the Abdomen |journal=Med Chir Trans |volume=75 |issue= |pages=109–18 |year=1892 |pmid=20896800 |pmc=2036288 |doi= |url=}}</ref>
  Name          = {{PAGENAME}} |
  Image          = |
  Caption        = |
  DiseasesDB    = 7943|
  ICD10          = |
  ICD9          = |
  ICDO          = |
  OMIM          = |
  MedlinePlus    = |
  eMedicineSubj  = |
  eMedicineTopic = |
}}
{{Meigs syndrome}}
{{CMG}}{{MV}}


{{SK}} Demons Meigs syndrome; Meigs-Cass syndrome; Meigs-Salmon syndrome
==Historical Perspective==
==[[Meigs syndrome overview|Overview]]==
*Meigs syndrome was first discovered by Otto von Spiegelberg, a German gynecologist, in 1866.<ref name="pmid20896800">{{cite journal |vauthors=Tait L |title=On the occurrence of Pleural Effusion in association with Disease of the Abdomen |journal=Med Chir Trans |volume=75 |issue= |pages=109–18 |year=1892 |pmid=20896800 |pmc=2036288 |doi= |url=}}</ref>
*Meigs syndrome is named after Joe Vincent Meigs, an American gynecologist who defined Meigs syndrome as the presence of ascites, hydrothorax, association with benign ovarian tumor.<ref name="pmid10996681">{{cite journal |vauthors=Lurie S |title=Meigs' syndrome: the history of the eponym |journal=Eur. J. Obstet. Gynecol. Reprod. Biol. |volume=92 |issue=2 |pages=199–204 |year=2000 |pmid=10996681 |doi= |url=}}</ref>
*In 1900, the first therapeutical surgical approach was developed by Albert Jean Octave Demons to treat Meigs syndrome.<ref name="pmid13148256">{{cite journal |vauthors=MEIGS JV |title=Fibroma of the ovary with ascites and hydrothorax; Meigs' syndrome |journal=Am. J. Obstet. Gynecol. |volume=67 |issue=5 |pages=962–85 |year=1954 |pmid=13148256 |doi= |url=}}</ref>


==[[Meigs syndrome historical perspective|Historical Perspective]]==
==Classification==
*There is no classification system established for Meigs syndrome.<ref name="pmid25662723">{{cite journal |vauthors=Gil A, Roque A, Alemán C |title=[Meigs' syndrome] |language=Spanish; Castilian |journal=Med Clin (Barc) |volume=145 |issue=2 |pages=95 |year=2015 |pmid=25662723 |doi=10.1016/j.medcli.2014.12.007 |url=}}</ref>
*Other variants of Meigs syndrome may include pseudo-meigs syndrome, and atypical Meigs' syndrome.


==[[Meigs syndrome classification|Classification]]==
==Pathophysiology==
*The pathogenesis of Meigs syndrome is characterized by the formation of the peritoneal and pleural effusion to the filtration of interstitial fluid in the peritoneum through the tumor capsule, and the diffusion to the pleural space.
*The [gene name] gene/Mutation in [gene name] has been associated with the development of Meigs syndrome, involving the [molecular pathway] pathway.
*On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of Meigs syndrome.
*On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of Meigs syndrome.
==Causes==
* Meigs syndrome may be caused by either [cause1], [cause2], or [cause3].
* Meigs syndrome is caused by a mutation in the [gene1], [gene2], or [gene3] gene[s].
* There are no established causes for Meigs syndrome.
==Differentiating Meigs syndrome from other Diseases==
*Meigs syndrome must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as:
:*[Differential dx1]
:*[Differential dx2]
:*[Differential dx3]
==Epidemiology and Demographics==
* The prevalence of Meigs syndrome is approximately [number or range] per 100,000 individuals worldwide.
* In [year], the incidence of Meigs syndrome was estimated to be [number or range] cases per 100,000 individuals in [location].
===Age===
*Patients of all age groups may develop Meigs syndrome.
*Meigs syndrome is more commonly observed among patients aged [age range] years old.
*Meigs syndrome is more commonly observed among [elderly patients/young patients/children].
===Gender===
*Meigs syndrome affects men and women equally.
*[Gender 1] are more commonly affected with Meigs syndrome than [gender 2].
* The [gender 1] to [Gender 2] ratio is approximately [number > 1] to 1.
===Race===
*There is no racial predilection for Meigs syndrome.
*Meigs syndrome usually affects individuals of the [race 1] race.
*[Race 2] individuals are less likely to develop Meigs syndrome.
==Risk Factors==
*Common risk factors in the development of Meigs syndrome are [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].
== Natural History, Complications and Prognosis==
*The majority of patients with Meigs syndrome remain asymptomatic for [duration/years].
*Early clinical features include [manifestation 1], [manifestation 2], and [manifestation 3].
*If left untreated, [#%] of patients with Meigs syndrome may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
*Common complications of Meigs syndrome include [complication 1], [complication 2], and [complication 3].
*Prognosis is generally [excellent/good/poor], and the [1/5/10­year mortality/survival rate] of patients with Meigs syndrome is approximately [#%].
== Diagnosis ==
===Diagnostic Criteria===
*The diagnosis of Meigs syndrome is made when at least [number] of the following [number] diagnostic criteria are met:
:*[criterion 1]
:*[criterion 2]
:*[criterion 3]
:*[criterion 4]
=== Symptoms ===
*Meigs syndrome is usually asymptomatic.
*Symptoms of Meigs syndrome may include the following:
:*[symptom 1]
:*[symptom 2]
:*[symptom 3]
:*[symptom 4]
:*[symptom 5]
:*[symptom 6]
=== Physical Examination ===
*Patients with Meigs syndrome usually appear [general appearance].
*Physical examination may be remarkable for:
:*[finding 1]
:*[finding 2]
:*[finding 3]
:*[finding 4]
:*[finding 5]
:*[finding 6]
=== Laboratory Findings ===
*There are no specific laboratory findings associated with Meigs syndrome.


==[[Meigs syndrome pathophysiology|Pathophysiology]]==
*A  [positive/negative] [test name] is diagnostic of Meigs syndrome.
*An [elevated/reduced] concentration of [serum/blood/urinary/CSF/other] [lab test] is diagnostic of Meigs syndrome.
*Other laboratory findings consistent with the diagnosis of Meigs syndrome include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
===Imaging Findings===
*There are no [imaging study] findings associated with Meigs syndrome.
*[Imaging study 1] is the imaging modality of choice for Meigs syndrome.
*On [imaging study 1], Meigs syndrome is characterized by [finding 1], [finding 2], and [finding 3].
*[Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].
=== Other Diagnostic Studies ===
*Meigs syndrome may also be diagnosed using [diagnostic study name].
*Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].
== Treatment ==
=== Medical Therapy ===
*There is no treatment for Meigs syndrome; the mainstay of therapy is supportive care.
*The mainstay of therapy for Meigs syndrome is [medical therapy 1] and [medical therapy 2].
*[Medical therapy 1] acts by [mechanism of action1].
*Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].
=== Surgery ===
*Surgery is the mainstay of therapy for Meigs syndrome.
*[Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of Meigs syndrome.
*[Surgical procedure] can only be performed for patients with [disease stage] Meigs syndrome.
=== Prevention ===
*There are no primary preventive measures available for Meigs syndrome.
*Effective measures for the primary prevention of Meigs syndrome include [measure1], [measure2], and [measure3].


==[[Meigs syndrome causes|Causes]]==
*Once diagnosed and successfully treated, patients with Meigs syndrome are followed-up every [duration]. Follow-up testing includes [test 1], [test 2], and [test 3].
 
==References==
==[[Meigs syndrome differential diagnosis|Differentiating Meigs Syndrome from other Diseases]]==
{{Reflist|2}}
 
==[[Meigs syndrome epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Meigs syndrome risk factors|Risk Factors]]==
 
==[[Meigs syndrome screening|Screening]]==
 
==[[Meigs syndrome natural history|Natural History, Complications and Prognosis]]==
 
==Diagnosis==
[[Meigs syndrome history and symptoms|History and Symptoms]] | [[Meigs syndrome physical examination|Physical Examination]] | [[Meigs syndrome laboratory tests|Laboratory Findings]] | [[Meigs syndrome chest x ray|Chest X Ray]] | [[Meigs syndrome CT|CT]] | [[Meigs syndrome MRI|MRI]] | [[Meigs syndrome echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Meigs syndrome other imaging findings|Other Imaging Findings]] | [[Meigs syndrome other diagnostic studies|Other Diagnostic Studies]]
 
==Treatment==
[[Meigs syndrome medical therapy|Medical Therapy]] | [[Meigs syndrome surgery|Surgery]] | [[Meigs syndrome primary prevention|Primary Prevention]] | [[Meigs syndrome secondary prevention|Secondary Prevention]] | [[Meigs syndrome cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Meigs syndrome future or investigational therapies|Future or Investigational Therapies]]
 
==Case Studies==
[[Meigs syndrome case study one|Case #1]]
 
 
[[Category:Disease]]
[[Category:Types of cancer]]
[[Category:Gynecology]]
[[Category:Oncology]]
 
[[pl:Zespół Meigsa]]
 
{{WH}}
{{WikiDoc Sources}}

Revision as of 21:21, 28 March 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Synonyms and keywords: Demons Meigs syndrome; Meigs-Cass syndrome; Meigs-Salmon syndrome

Overview

Meigs syndrome (also known as "Demons Meigs syndrome") is defined as the triad of ascites, pleural effusion, and benign ovarian tumor (fibroma, Brenner tumour and occasionally granulosa cell tumour). Meigs syndrome was first discovered by Otto von Spiegelberg, a German gynecologist, in 1866.[1]

Historical Perspective

  • Meigs syndrome was first discovered by Otto von Spiegelberg, a German gynecologist, in 1866.[1]
  • Meigs syndrome is named after Joe Vincent Meigs, an American gynecologist who defined Meigs syndrome as the presence of ascites, hydrothorax, association with benign ovarian tumor.[2]
  • In 1900, the first therapeutical surgical approach was developed by Albert Jean Octave Demons to treat Meigs syndrome.[3]

Classification

  • There is no classification system established for Meigs syndrome.[4]
  • Other variants of Meigs syndrome may include pseudo-meigs syndrome, and atypical Meigs' syndrome.

Pathophysiology

  • The pathogenesis of Meigs syndrome is characterized by the formation of the peritoneal and pleural effusion to the filtration of interstitial fluid in the peritoneum through the tumor capsule, and the diffusion to the pleural space.
  • The [gene name] gene/Mutation in [gene name] has been associated with the development of Meigs syndrome, involving the [molecular pathway] pathway.
  • On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of Meigs syndrome.
  • On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of Meigs syndrome.

Causes

  • Meigs syndrome may be caused by either [cause1], [cause2], or [cause3].
  • Meigs syndrome is caused by a mutation in the [gene1], [gene2], or [gene3] gene[s].
  • There are no established causes for Meigs syndrome.

Differentiating Meigs syndrome from other Diseases

  • Meigs syndrome must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as:
  • [Differential dx1]
  • [Differential dx2]
  • [Differential dx3]

Epidemiology and Demographics

  • The prevalence of Meigs syndrome is approximately [number or range] per 100,000 individuals worldwide.
  • In [year], the incidence of Meigs syndrome was estimated to be [number or range] cases per 100,000 individuals in [location].

Age

  • Patients of all age groups may develop Meigs syndrome.
  • Meigs syndrome is more commonly observed among patients aged [age range] years old.
  • Meigs syndrome is more commonly observed among [elderly patients/young patients/children].

Gender

  • Meigs syndrome affects men and women equally.
  • [Gender 1] are more commonly affected with Meigs syndrome than [gender 2].
  • The [gender 1] to [Gender 2] ratio is approximately [number > 1] to 1.

Race

  • There is no racial predilection for Meigs syndrome.
  • Meigs syndrome usually affects individuals of the [race 1] race.
  • [Race 2] individuals are less likely to develop Meigs syndrome.

Risk Factors

  • Common risk factors in the development of Meigs syndrome are [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].

Natural History, Complications and Prognosis

  • The majority of patients with Meigs syndrome remain asymptomatic for [duration/years].
  • Early clinical features include [manifestation 1], [manifestation 2], and [manifestation 3].
  • If left untreated, [#%] of patients with Meigs syndrome may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
  • Common complications of Meigs syndrome include [complication 1], [complication 2], and [complication 3].
  • Prognosis is generally [excellent/good/poor], and the [1/5/10­year mortality/survival rate] of patients with Meigs syndrome is approximately [#%].

Diagnosis

Diagnostic Criteria

  • The diagnosis of Meigs syndrome is made when at least [number] of the following [number] diagnostic criteria are met:
  • [criterion 1]
  • [criterion 2]
  • [criterion 3]
  • [criterion 4]

Symptoms

  • Meigs syndrome is usually asymptomatic.
  • Symptoms of Meigs syndrome may include the following:
  • [symptom 1]
  • [symptom 2]
  • [symptom 3]
  • [symptom 4]
  • [symptom 5]
  • [symptom 6]

Physical Examination

  • Patients with Meigs syndrome usually appear [general appearance].
  • Physical examination may be remarkable for:
  • [finding 1]
  • [finding 2]
  • [finding 3]
  • [finding 4]
  • [finding 5]
  • [finding 6]

Laboratory Findings

  • There are no specific laboratory findings associated with Meigs syndrome.
  • A [positive/negative] [test name] is diagnostic of Meigs syndrome.
  • An [elevated/reduced] concentration of [serum/blood/urinary/CSF/other] [lab test] is diagnostic of Meigs syndrome.
  • Other laboratory findings consistent with the diagnosis of Meigs syndrome include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

Imaging Findings

  • There are no [imaging study] findings associated with Meigs syndrome.
  • [Imaging study 1] is the imaging modality of choice for Meigs syndrome.
  • On [imaging study 1], Meigs syndrome is characterized by [finding 1], [finding 2], and [finding 3].
  • [Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].

Other Diagnostic Studies

  • Meigs syndrome may also be diagnosed using [diagnostic study name].
  • Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].

Treatment

Medical Therapy

  • There is no treatment for Meigs syndrome; the mainstay of therapy is supportive care.
  • The mainstay of therapy for Meigs syndrome is [medical therapy 1] and [medical therapy 2].
  • [Medical therapy 1] acts by [mechanism of action1].
  • Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].

Surgery

  • Surgery is the mainstay of therapy for Meigs syndrome.
  • [Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of Meigs syndrome.
  • [Surgical procedure] can only be performed for patients with [disease stage] Meigs syndrome.

Prevention

  • There are no primary preventive measures available for Meigs syndrome.
  • Effective measures for the primary prevention of Meigs syndrome include [measure1], [measure2], and [measure3].
  • Once diagnosed and successfully treated, patients with Meigs syndrome are followed-up every [duration]. Follow-up testing includes [test 1], [test 2], and [test 3].

References

  1. ↑ 1.0 1.1 Tait L (1892). "On the occurrence of Pleural Effusion in association with Disease of the Abdomen". Med Chir Trans. 75: 109–18. PMC 2036288. PMID 20896800.
  2. ↑ Lurie S (2000). "Meigs' syndrome: the history of the eponym". Eur. J. Obstet. Gynecol. Reprod. Biol. 92 (2): 199–204. PMID 10996681.
  3. ↑ MEIGS JV (1954). "Fibroma of the ovary with ascites and hydrothorax; Meigs' syndrome". Am. J. Obstet. Gynecol. 67 (5): 962–85. PMID 13148256.
  4. ↑ Gil A, Roque A, Alemán C (2015). "[Meigs' syndrome]". Med Clin (Barc) (in Spanish; Castilian). 145 (2): 95. doi:10.1016/j.medcli.2014.12.007. PMID 25662723.
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