Appendix cancer

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List of terms related to Appendix cancer

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Synonyms and keywords: Synonym 1; Synonym 2; Synonym 3

Overview

Appendix cancer ( also known as appendiceal cancer) is a rare malignancy of the vermiform appendix. The most common type of appendix cancer is carcinoid tumor. Appendix cancers often present with peritoneal seeding, resulting in peritoneal carcinomatosis or pseudomyxoma peritonei.

Historical Perspective

• Appendix cancer was first discovered by Siegfried Oberndorfer, a German Physician, in 1907.
• In 1894, the first surgery also known as McBurney's incision was developed by Charles Heber McBurney, an American surgeon, to treat appendix cancer.

Classification

• Appendix cancer may be classified according to WHO classification into 4 groups:

• Epithelial tumors
• Non-epithelial tumors
• Secondary tumors
• Hyperplastic (metaplastic) polyp

• The table below summarizes the different types of appendix cancer according to the WHO classification

Pathophysiology

• The pathogenesis of appendix cancer is characterized by a chronic inflammatory process.
• The KRAS gene mutation has been associated with the development of appendix cancer.
• On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of appendix cancer.
• On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of appendix cancer.

Causes

• Appendix cancer may be caused by either [cause1], [cause2], or [cause3].
• Appendix cancer is caused by a mutation in the [gene1], [gene2], or [gene3] gene[s].
• There are no established causes for appendix cancer.

Differentiating appendix cancer from other Diseases

• Appendix cancer must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as:

• [Differential dx1]
• [Differential dx2]
• [Differential dx3]

Epidemiology and Demographics

• The prevalence of appendix cancer is approximately [number or range] per 100,000 individuals worldwide.
• In [year], the incidence of appendix cancer was estimated to be [number or range] cases per 100,000 individuals in [location].

Age

• Patients of all age groups may develop appendix cancer.

• Appendix cancer is more commonly observed among patients aged [age range] years old.
• Appendix cancer is more commonly observed among [elderly patients/young patients/children].

Gender

• Appendix cancer affects men and women equally.

• [Gender 1] are more commonly affected with appendix cancer than [gender 2].
• The [gender 1] to [Gender 2] ratio is approximately [number > 1] to 1.

Race

• There is no racial predilection for appendix cancer.

• Appendix cancer usually affects individuals of the [race 1] race.
• [Race 2] individuals are less likely to develop appendix cancer.

Risk Factors

• Common risk factors in the development of appendix cancer are [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].

Natural History, Complications and Prognosis

• The majority of patients with appendix cancer remain asymptomatic for [duration/years].
• Early clinical features include [manifestation 1], [manifestation 2], and [manifestation 3].
• If left untreated, [#%] of patients with appendix cancer may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
• Common complications of appendix cancer include [complication 1], [complication 2], and [complication 3].
• Prognosis is generally [excellent/good/poor], and the [1/5/10­year mortality/survival rate] of patients with appendix cancer is approximately [#%].

Diagnosis

Diagnostic Criteria

• The diagnosis of appendix cancer is made when at least [number] of the following [number] diagnostic criteria are met:

• [criterion 1]
• [criterion 2]
• [criterion 3]
• [criterion 4]

Symptoms

• Appendix cancer is usually asymptomatic.
• Symptoms of appendix cancer may include the following:

• [symptom 1]
• [symptom 2]
• [symptom 3]
• [symptom 4]
• [symptom 5]
• [symptom 6]

Physical Examination

• Patients with appendix cancer usually appear [general appearance].
• Physical examination may be remarkable for:

• [finding 1]
• [finding 2]
• [finding 3]
• [finding 4]
• [finding 5]
• [finding 6]

Laboratory Findings

• There are no specific laboratory findings associated with appendix cancer.

• A [positive/negative] [test name] is diagnostic of appendix cancer.
• An [elevated/reduced] concentration of [serum/blood/urinary/CSF/other] [lab test] is diagnostic of appendix cancer.
• Other laboratory findings consistent with the diagnosis of appendix cancer include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

Imaging Findings

• There are no [imaging study] findings associated with appendix cancer.

• [Imaging study 1] is the imaging modality of choice for appendix cancer.
• On [imaging study 1], appendix cancer is characterized by [finding 1], [finding 2], and [finding 3].
• [Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].

Other Diagnostic Studies

• Appendix cancer may also be diagnosed using [diagnostic study name].
• Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].

Treatment

Medical Therapy

• There is no treatment for appendix cancer; the mainstay of therapy is supportive care.

• The mainstay of therapy for appendix cancer is [medical therapy 1] and [medical therapy 2].
• [Medical therapy 1] acts by [mechanism of action1].
• Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].

Surgery

• Surgery is the mainstay of therapy for appendix cancer.
• [Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of appendix cancer.
• [Surgical procedure] can only be performed for patients with [disease stage] appendix cancer.

Prevention

• There are no primary preventive measures available for appendix cancer.

• Effective measures for the primary prevention of appendix cancer include [measure1], [measure2], and [measure3].

• Once diagnosed and successfully treated, patients with appendix cancer are followed-up every [duration]. Follow-up testing includes [test 1], [test 2], and [test 3].