Lobular carcinoma in situ: Difference between revisions
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*The pathogenesis of [disease name] is characterized by [feature1], [feature2], and [feature3]. | *The pathogenesis of [disease name] is characterized by [feature1], [feature2], and [feature3]. | ||
*The loss of expression of [[e-cadherin]], the [[transmembrane]] [[protein]] mediating [[epithelial]] [[cell adhesion]] has been associated with the development of lobular carcinoma in situ. | *The loss of expression of [[e-cadherin]], the [[transmembrane]] [[protein]] mediating [[epithelial]] [[cell adhesion]] has been associated with the development of lobular carcinoma in situ. | ||
*The loss of heterozygosity on chromosome 16q has been associated with the development of lobular carcinoma in situ. | *The loss of heterozygosity on chromosome 16q has been associated with the development of lobular carcinoma in situ.. | ||
*On microscopic histopathological analysis, small cells with oval or round nuclei and small nucleoli detached from each other are [[mucin]]-containing signet-ring cells are characteristic findings of lobular carcinoma in situ | *On microscopic histopathological analysis, small cells with oval or round nuclei and small nucleoli detached from each other are [[mucin]]-containing signet-ring cells are characteristic findings of lobular carcinoma in situ | ||
==Causes== | ==Causes== | ||
* Lobular carcinoma in situ is caused by a mutation in the [[e-cadherin]] gene. | * Lobular carcinoma in situ is caused by a mutation in the [[e-cadherin]] gene. | ||
Revision as of 21:14, 20 April 2016
For patient information click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]; Ammu Susheela, M.D. [3]
Synonyms and keywords: Synonym 1; Synonym 2; Synonym 3
Overview
Historical Perspective
- Lobular carcinoma in situ was first discovered by F W Foote and F W Stewart, in 1941.
Pathophysiology
- Lobular carcinoma in situ (LCIS) is a condition in which there is presence of unusual cells in the lobules of the breast.[1]
- The pathogenesis of [disease name] is characterized by [feature1], [feature2], and [feature3].
- The loss of expression of e-cadherin, the transmembrane protein mediating epithelial cell adhesion has been associated with the development of lobular carcinoma in situ.
- The loss of heterozygosity on chromosome 16q has been associated with the development of lobular carcinoma in situ..
- On microscopic histopathological analysis, small cells with oval or round nuclei and small nucleoli detached from each other are mucin-containing signet-ring cells are characteristic findings of lobular carcinoma in situ
Causes
- Lobular carcinoma in situ is caused by a mutation in the e-cadherin gene.
Differentiating Lobular carcinoma in situ from other Diseases
- Lobular carcinoma in situ must be differentiated from other diseases that cause breast lesions, such as:
- Ductal carcinoma insitu
- Atypical lobular hyperplasia
Epidemiology and Demographics
- The prevalence of [disease name] is approximately [number or range] per 100,000 individuals worldwide.
- In [year], the incidence of [disease name] was estimated to be [number or range] cases per 100,000 individuals in [location].
Age
- Lobular carcinoma in situ is more commonly observed among patients aged premenopausal women with a mean age of 45 years old
Race
- There is no racial predilection for [disease name].
- [Disease name] usually affects individuals of the [race 1] race.
- [Race 2] individuals are less likely to develop [disease name].
Risk Factors
- Common risk factors in the development of [disease name] are [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].
Natural History, Complications and Prognosis
- The majority of patients with [disease name] remain asymptomatic for [duration/years].
- Early clinical features include [manifestation 1], [manifestation 2], and [manifestation 3].
- If left untreated, [#%] of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
- Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
- Prognosis is generally [excellent/good/poor], and the [1/5/10year mortality/survival rate] of patients with [disease name] is approximately [#%].
Diagnosis
Diagnostic Criteria
- The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met:
- [criterion 1]
- [criterion 2]
- [criterion 3]
- [criterion 4]
Symptoms
- [Disease name] is usually asymptomatic.
- Symptoms of [disease name] may include the following:
- [symptom 1]
- [symptom 2]
- [symptom 3]
- [symptom 4]
- [symptom 5]
- [symptom 6]
Physical Examination
- Patients with [disease name] usually appear [general appearance].
- Physical examination may be remarkable for:
- [finding 1]
- [finding 2]
- [finding 3]
- [finding 4]
- [finding 5]
- [finding 6]
Laboratory Findings
- There are no specific laboratory findings associated with [disease name].
- A [positive/negative] [test name] is diagnostic of [disease name].
- An [elevated/reduced] concentration of [serum/blood/urinary/CSF/other] [lab test] is diagnostic of [disease name].
- Other laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
Imaging Findings
- There are no [imaging study] findings associated with [disease name].
- [Imaging study 1] is the imaging modality of choice for [disease name].
- On [imaging study 1], [disease name] is characterized by [finding 1], [finding 2], and [finding 3].
- [Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].
Other Diagnostic Studies
- [Disease name] may also be diagnosed using [diagnostic study name].
- Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].
Treatment
Medical Therapy
- There is no treatment for [disease name]; the mainstay of therapy is supportive care.
- The mainstay of therapy for [disease name] is [medical therapy 1] and [medical therapy 2].
- [Medical therapy 1] acts by [mechanism of action1].
- Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].
Surgery
- Surgery is the mainstay of therapy for [disease name].
- [Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of [disease name].
- [Surgical procedure] can only be performed for patients with [disease stage] [disease name].
Prevention
- There are no primary preventive measures available for [disease name].
- Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].
- Once diagnosed and successfully treated, patients with [disease name] are followedup every [duration]. Followup testing includes [test 1], [test 2], and [test 3].