Celiac disease epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
Celiac Disease is more prevalent than previously thought. Prevalence has been shown to be as high as 1:250 <ref>Detecting Celiac Disease in Your Patients", American Family Physician, Vol. 57/No. 5, Pruessner, Harold T., M.D. http://www.aafp.org/afp/980301ap/pruessn.html</ref> ). The prevalence may be as high as 1:133 in the general population. | Celiac Disease is more prevalent than previously thought. Prevalence has been shown to be as high as 1:250 <ref>Detecting Celiac Disease in Your Patients", American Family Physician, Vol. 57/No. 5, Pruessner, Harold T., M.D. http://www.aafp.org/afp/980301ap/pruessn.html</ref> ). The prevalence may be as high as 1:133 in the general population. | ||
==Prevalence== | ==Epidemiology and Demographics== | ||
===Prevalence=== | |||
The prevalence of clinically diagnosed disease (symptoms prompting diagnostic testing) is 0.05–0.27% in various studies. However, population studies from parts of Europe, India, South America, Australasia and the USA (using serology and biopsy) indicate that the prevalence may be between 0.33 and 1.06% in children (5.66% in one study of Saharawi children<ref name="Catassi1999">{{cite journal | author = Catassi C, Rätsch I, Gandolfi L, Pratesi R, Fabiani E, El Asmar R, Frijia M, Bearzi I, Vizzoni L | title = Why is coeliac disease endemic in the people of the Sahara? | journal = Lancet | volume = 354 | issue = 9179 | pages = 647–8 | year = 1999|id = PMID 10466670}}</ref>) and 0.18–1.2% in adults. People of African, Japanese and Chinese descent are rarely diagnosed; this reflects a much lower prevalence of the genetic risk factors. Population studies also indicate that a large proportion of coeliacs remain undiagnosed; this is due to many clinicians being unfamiliar with the condition.<ref>{{cite journal |author=Zipser R, Farid M, Baisch D, Patel B, Patel D |title=Physician awareness of celiac disease: a need for further education |journal=J Gen Intern Med |volume=20 |issue=7 |pages=644-6 |year=2005 |pmid=16050861}}</ref> | The prevalence of clinically diagnosed disease (symptoms prompting diagnostic testing) is 0.05–0.27% in various studies. However, population studies from parts of Europe, India, South America, Australasia and the USA (using serology and biopsy) indicate that the prevalence may be between 0.33 and 1.06% in children (5.66% in one study of Saharawi children<ref name="Catassi1999">{{cite journal | author = Catassi C, Rätsch I, Gandolfi L, Pratesi R, Fabiani E, El Asmar R, Frijia M, Bearzi I, Vizzoni L | title = Why is coeliac disease endemic in the people of the Sahara? | journal = Lancet | volume = 354 | issue = 9179 | pages = 647–8 | year = 1999|id = PMID 10466670}}</ref>) and 0.18–1.2% in adults. People of African, Japanese and Chinese descent are rarely diagnosed; this reflects a much lower prevalence of the genetic risk factors. Population studies also indicate that a large proportion of coeliacs remain undiagnosed; this is due to many clinicians being unfamiliar with the condition.<ref>{{cite journal |author=Zipser R, Farid M, Baisch D, Patel B, Patel D |title=Physician awareness of celiac disease: a need for further education |journal=J Gen Intern Med |volume=20 |issue=7 |pages=644-6 |year=2005 |pmid=16050861}}</ref> | ||
A large multicentre study in the U.S. found a prevalence of 0.75% in not-at-risk groups, rising to 1.8% in symptomatic patients, 2.6% in second-degree relatives of a patient with coeliac disease and 4.5% in first-degree relatives. This profile is similar to the prevalence in Europe.<ref name="Fasano2003">{{cite journal | author = Fasano A, Berti I, Gerarduzzi T, Not T, Colletti R, Drago S, Elitsur Y, Green P, Guandalini S, Hill I, Pietzak M, Ventura A, Thorpe M, Kryszak D, Fornaroli F, Wasserman S, Murray J, Horvath K | title = Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study | journal = Archives of Internal Medicine | volume = 163 | issue = 3 | pages = 286–92 | year = 2003 | url = http://archinte.ama-assn.org/cgi/content/full/163/3/286 | id = PMID 12578508}}</ref> | A large multicentre study in the U.S. found a prevalence of 0.75% in not-at-risk groups, rising to 1.8% in symptomatic patients, 2.6% in second-degree relatives of a patient with coeliac disease and 4.5% in first-degree relatives. This profile is similar to the prevalence in Europe.<ref name="Fasano2003">{{cite journal | author = Fasano A, Berti I, Gerarduzzi T, Not T, Colletti R, Drago S, Elitsur Y, Green P, Guandalini S, Hill I, Pietzak M, Ventura A, Thorpe M, Kryszak D, Fornaroli F, Wasserman S, Murray J, Horvath K | title = Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study | journal = Archives of Internal Medicine | volume = 163 | issue = 3 | pages = 286–92 | year = 2003 | url = http://archinte.ama-assn.org/cgi/content/full/163/3/286 | id = PMID 12578508}}</ref> | ||
===Incidence=== | |||
===Case Fatality Rate=== | |||
===Age=== | |||
===Gender=== | |||
===Race=== | |||
===Developed Countries=== | |||
===Developing Countries=== | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Celiac Disease is more prevalent than previously thought. Prevalence has been shown to be as high as 1:250 [1] ). The prevalence may be as high as 1:133 in the general population.
Epidemiology and Demographics
Prevalence
The prevalence of clinically diagnosed disease (symptoms prompting diagnostic testing) is 0.05–0.27% in various studies. However, population studies from parts of Europe, India, South America, Australasia and the USA (using serology and biopsy) indicate that the prevalence may be between 0.33 and 1.06% in children (5.66% in one study of Saharawi children[2]) and 0.18–1.2% in adults. People of African, Japanese and Chinese descent are rarely diagnosed; this reflects a much lower prevalence of the genetic risk factors. Population studies also indicate that a large proportion of coeliacs remain undiagnosed; this is due to many clinicians being unfamiliar with the condition.[3]
A large multicentre study in the U.S. found a prevalence of 0.75% in not-at-risk groups, rising to 1.8% in symptomatic patients, 2.6% in second-degree relatives of a patient with coeliac disease and 4.5% in first-degree relatives. This profile is similar to the prevalence in Europe.[4]
Incidence
Case Fatality Rate
Age
Gender
Race
Developed Countries
Developing Countries
References
- ↑ Detecting Celiac Disease in Your Patients", American Family Physician, Vol. 57/No. 5, Pruessner, Harold T., M.D. http://www.aafp.org/afp/980301ap/pruessn.html
- ↑ Catassi C, Rätsch I, Gandolfi L, Pratesi R, Fabiani E, El Asmar R, Frijia M, Bearzi I, Vizzoni L (1999). "Why is coeliac disease endemic in the people of the Sahara?". Lancet. 354 (9179): 647–8. PMID 10466670.
- ↑ Zipser R, Farid M, Baisch D, Patel B, Patel D (2005). "Physician awareness of celiac disease: a need for further education". J Gen Intern Med. 20 (7): 644–6. PMID 16050861.
- ↑ Fasano A, Berti I, Gerarduzzi T, Not T, Colletti R, Drago S, Elitsur Y, Green P, Guandalini S, Hill I, Pietzak M, Ventura A, Thorpe M, Kryszak D, Fornaroli F, Wasserman S, Murray J, Horvath K (2003). "Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study". Archives of Internal Medicine. 163 (3): 286–92. PMID 12578508.