Hereditary spherocytosis differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Differential diagnosis

• Glucose-6-phosphate dehydrogenase deficiency
• Hemoglobin H disease
• Autoimmune hemolytic anemias or alloimmune hemolytic anemia (eg, ABO incompatibility)
• Extrinsic nonimmune hemolytic anemia due to systemic disease
• Microangiopathic hemolytic anemia