Hereditary spherocytosis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Laboratory Findings

Red cell indices

• Reticulocytosis
• Decreased mean corpuscular volume
• Increased mean corpuscular hemoglobin concentration
• Increased red cell distribution width

Peripheral blood smear

• In a peripheral blood smear, the abnormally small red blood cells lacking the central pallor i.e. spherocytes are seen.