Thrombophilia differential diagnosis: Difference between revisions
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{{Thrombophilia}} | {{Thrombophilia}} | ||
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==Overview== | ==Overview== | ||
*Inherited thrombophilia must be differentiated from acquired thrombophilia, as it may influence the selection and duration of [[Anticoagulant|anticoagulation]]. | |||
*Inherited thrombophilias should be suspected in patients with the certain clinical presentations<ref name="pmid24421360">{{cite journal| author=Cohoon KP, Heit JA| title=Inherited and secondary thrombophilia. | journal=Circulation | year= 2014 | volume= 129 | issue= 2 | pages= 254-7 | pmid=24421360 | doi=10.1161/CIRCULATIONAHA.113.001943 | pmc=3979345 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24421360 }} </ref>. | |||
*Screening for inherited thrombophilias is controversial and should be performed in the appropriate clinical context. | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
*Inherited thrombophilias should be suspected in following clinical presentations: | |||
**Family history of thrombosis, especially at an early age | |||
**Unprovoked thrombosis at an early age (<40-55 for venous thrombosis and <50-55 for arterial thrombosis) | |||
**Recurrent thrombosis | |||
**Thrombosis at multiple sites, or unusual locations including in cerebral, splanchnic, and renal veins. | |||
**Thrombosis in arteries with the abscence of arterial disease | |||
**History of fetal loss | |||
==References== | ==References== |
Revision as of 21:00, 24 June 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Asiri Ediriwickrema, M.D., M.H.S. [2]
Overview
- Inherited thrombophilia must be differentiated from acquired thrombophilia, as it may influence the selection and duration of anticoagulation.
- Inherited thrombophilias should be suspected in patients with the certain clinical presentations[1].
- Screening for inherited thrombophilias is controversial and should be performed in the appropriate clinical context.
Differential Diagnosis
- Inherited thrombophilias should be suspected in following clinical presentations:
- Family history of thrombosis, especially at an early age
- Unprovoked thrombosis at an early age (<40-55 for venous thrombosis and <50-55 for arterial thrombosis)
- Recurrent thrombosis
- Thrombosis at multiple sites, or unusual locations including in cerebral, splanchnic, and renal veins.
- Thrombosis in arteries with the abscence of arterial disease
- History of fetal loss
References
- ↑ Cohoon KP, Heit JA (2014). "Inherited and secondary thrombophilia". Circulation. 129 (2): 254–7. doi:10.1161/CIRCULATIONAHA.113.001943. PMC 3979345. PMID 24421360.