Achalasia overview: Difference between revisions
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==Overview== | ==Overview== | ||
'''Achalasia''' is a primary [[esophageal motility disorder]] of unknown etiology.<ref name="pmid23877351">{{cite journal| author=Vaezi MF, Pandolfino JE, Vela MF| title=ACG clinical guideline: diagnosis and management of achalasia. | journal=Am J Gastroenterol | year= 2013 | volume= 108 | issue= 8 | pages= 1238-49; quiz 1250 | pmid=23877351 | doi=10.1038/ajg.2013.196 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23877351 }} </ref><ref name=Kraichely_2006>{{cite journal |author=Kraichely R, Farrugia G |title=Achalasia: physiology and etiopathogenesis |journal=Dis Esophagus |volume=19 |issue=4 |pages=213-23 |year=2006 |pmid=16866850}}</ref>In this disorder, the [[smooth muscle cell|smooth muscle]] layer of the [[esophagus]] has impaired [[peristalsis]] (muscular ability to move food down the esophagus), and the [[lower esophageal sphincter]] (LES) fails to relax properly in response to [[swallowing]] due to absent enteric neurons.<ref name=Park_2005>{{cite journal |author=Park W, Vaezi M |title=Etiology and pathogenesis of achalasia: the current understanding |journal=Am J Gastroenterol |volume=100 |issue=6 |pages=1404-14 |year=2005 |pmid=15929777}}</ref> It should be differentiated from pseudoachalasia (caused by neoplastic infiltration of myenteric neurons) and secondary achalasia (caused by extrinsic procedures such as previous [[fundoplication]] and [[Adjustable gastric banding surgery|gastric banding]]). [[Trypanosoma cruzi]] infection causing [[Chagas disease]] can also result in achalasia. It is an incurable chronic condition.<ref name="pmid23877351">{{cite journal| author=Vaezi MF, Pandolfino JE, Vela MF| title=ACG clinical guideline: diagnosis and management of achalasia. | journal=Am J Gastroenterol | year= 2013 | volume= 108 | issue= 8 | pages= 1238-49; quiz 1250 | pmid=23877351 | doi=10.1038/ajg.2013.196 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23877351 }} </ref> | '''Achalasia''' is a primary [[esophageal motility disorder]] of unknown etiology.<ref name="pmid23877351">{{cite journal| author=Vaezi MF, Pandolfino JE, Vela MF| title=ACG clinical guideline: diagnosis and management of achalasia. | journal=Am J Gastroenterol | year= 2013 | volume= 108 | issue= 8 | pages= 1238-49; quiz 1250 | pmid=23877351 | doi=10.1038/ajg.2013.196 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23877351 }} </ref><ref name=Kraichely_2006>{{cite journal |author=Kraichely R, Farrugia G |title=Achalasia: physiology and etiopathogenesis |journal=Dis Esophagus |volume=19 |issue=4 |pages=213-23 |year=2006 |pmid=16866850}}</ref>In this disorder, the [[smooth muscle cell|smooth muscle]] layer of the [[esophagus]] has impaired [[peristalsis]] (muscular ability to move food down the esophagus), and the [[lower esophageal sphincter]] (LES) fails to relax properly in response to [[swallowing]] due to absent enteric neurons.<ref name=Park_2005>{{cite journal |author=Park W, Vaezi M |title=Etiology and pathogenesis of achalasia: the current understanding |journal=Am J Gastroenterol |volume=100 |issue=6 |pages=1404-14 |year=2005 |pmid=15929777}}</ref> It should be differentiated from pseudoachalasia (caused by neoplastic infiltration of myenteric neurons) and secondary achalasia (caused by extrinsic procedures such as previous [[fundoplication]] and [[Adjustable gastric banding surgery|gastric banding]]). [[Trypanosoma cruzi]] infection causing [[Chagas disease]] can also result in achalasia. It is an incurable chronic condition.<ref name="pmid23877351">{{cite journal| author=Vaezi MF, Pandolfino JE, Vela MF| title=ACG clinical guideline: diagnosis and management of achalasia. | journal=Am J Gastroenterol | year= 2013 | volume= 108 | issue= 8 | pages= 1238-49; quiz 1250 | pmid=23877351 | doi=10.1038/ajg.2013.196 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23877351 }} </ref> | ||
==Historical Perspective== | |||
==Classification== | |||
==Pathophysiology== | |||
==Causes== | |||
==Differentiating {{PAGENAME}} from Other Diseases== | |||
==Epidemiology and Demographics== | |||
==Risk Factors== | |||
==Screening== | |||
==Natural History, Complications, and Prognosis== | |||
===Natural History=== | |||
===Complications=== | |||
===Prognosis=== | |||
==Diagnosis== | |||
===Diagnostic Criteria=== | |||
===History and Symptoms=== | |||
===Physical Examination=== | |||
===Laboratory Findings=== | |||
===Imaging Findings=== | |||
===Other Diagnostic Studies=== | |||
==Treatment== | |||
===Medical Therapy=== | |||
===Surgery=== | |||
===Prevention=== | |||
==References== | ==References== | ||
{{Reflist|2}} | |||
{{ | [[Category:Gastroenterology]] | ||
[[Category:Otolaryngology]] | |||
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Revision as of 19:33, 6 July 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Twinkle Singh, M.B.B.S. [2]
Overview
Achalasia is a primary esophageal motility disorder of unknown etiology.[1][2]In this disorder, the smooth muscle layer of the esophagus has impaired peristalsis (muscular ability to move food down the esophagus), and the lower esophageal sphincter (LES) fails to relax properly in response to swallowing due to absent enteric neurons.[3] It should be differentiated from pseudoachalasia (caused by neoplastic infiltration of myenteric neurons) and secondary achalasia (caused by extrinsic procedures such as previous fundoplication and gastric banding). Trypanosoma cruzi infection causing Chagas disease can also result in achalasia. It is an incurable chronic condition.[1]
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Achalasia overview from Other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications, and Prognosis
Natural History
Complications
Prognosis
Diagnosis
Diagnostic Criteria
History and Symptoms
Physical Examination
Laboratory Findings
Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Prevention
References
- ↑ 1.0 1.1 Vaezi MF, Pandolfino JE, Vela MF (2013). "ACG clinical guideline: diagnosis and management of achalasia". Am J Gastroenterol. 108 (8): 1238–49, quiz 1250. doi:10.1038/ajg.2013.196. PMID 23877351.
- ↑ Kraichely R, Farrugia G (2006). "Achalasia: physiology and etiopathogenesis". Dis Esophagus. 19 (4): 213–23. PMID 16866850.
- ↑ Park W, Vaezi M (2005). "Etiology and pathogenesis of achalasia: the current understanding". Am J Gastroenterol. 100 (6): 1404–14. PMID 15929777.