Thrombophilia risk factors: Difference between revisions
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==Overview== | ==Overview== | ||
The most common risk factors in the development of acquired thrombophlias are trauma, surgery, immobility, pregnancy, | The most common risk factors in the development of acquired thrombophlias are [[trauma]], [[surgery]], [[immobility]], pregnancy, [[oral contraceptives]], [[hormone replacement therapy]], and age. Common risk factors for the development of inherited thrombophilias are a family history of [[thrombosis]] at an early age or a family history of inherited thrombophilia. Common genetic risk factors in the development of inherited thrombophilias are mutations in [[Factor_V_Leiden|factor V leiden]] and [[prothrombin]] G20210A. | ||
==Risk Factors== | ==Risk Factors== | ||
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Common risk factors for the development of inherited thrombophilias are a family history of thrombosis at an early age or a family history of inherited thrombophilia. | Common risk factors for the development of inherited thrombophilias are a family history of thrombosis at an early age or a family history of inherited thrombophilia. | ||
Common genetic risk factors in the development of inherited thrombophilias are mutations in [[Factor V Leiden]] and [[ | Common genetic risk factors in the development of inherited thrombophilias are mutations in [[Factor_V_Leiden|Factor V Leiden]] and [[Prothrombin G20210A]].<ref name="pmid24421360">{{cite journal| author=Cohoon KP, Heit JA| title=Inherited and secondary thrombophilia. | journal=Circulation | year= 2014 | volume= 129 | issue= 2 | pages= 254-7 | pmid=24421360 | doi=10.1161/CIRCULATIONAHA.113.001943 | pmc=3979345 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24421360 }} </ref><ref name="pmid11309638">{{cite journal| author=Seligsohn U, Lubetsky A| title=Genetic susceptibility to venous thrombosis. | journal=N Engl J Med | year= 2001 | volume= 344 | issue= 16 | pages= 1222-31 | pmid=11309638 | doi=10.1056/NEJM200104193441607 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11309638 }} </ref><ref name="pmid21340752">{{cite journal| author=Middeldorp S| title=Evidence-based approach to thrombophilia testing. | journal=J Thromb Thrombolysis | year= 2011 | volume= 31 | issue= 3 | pages= 275-81 | pmid=21340752 | doi=10.1007/s11239-011-0572-y | pmc=3056012 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21340752 }} </ref> | ||
Please see [[Thrombophilia classification|thrombophilia classification]] for a list conditions associated with acquired thrombophilias, and to the page on [[Thrombophilia_causes|causes of thrombophilia by organ system]]. | Please see [[Thrombophilia classification|thrombophilia classification]] for a list conditions associated with acquired thrombophilias, and to the page on [[Thrombophilia_causes|causes of thrombophilia by organ system]]. | ||
Revision as of 19:15, 21 July 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Asiri Ediriwickrema, M.D., M.H.S. [2]
Overview
The most common risk factors in the development of acquired thrombophlias are trauma, surgery, immobility, pregnancy, oral contraceptives, hormone replacement therapy, and age. Common risk factors for the development of inherited thrombophilias are a family history of thrombosis at an early age or a family history of inherited thrombophilia. Common genetic risk factors in the development of inherited thrombophilias are mutations in factor V leiden and prothrombin G20210A.
Risk Factors
- The most common risk factors in the development of acquired thrombophlias are the following:
- Trauma
- Surgery
- Immobility
- Age
- Hormones
- Pregnancy
- Oral contraceptive pills
- Hormone therapy
Common risk factors for the development of inherited thrombophilias are a family history of thrombosis at an early age or a family history of inherited thrombophilia.
Common genetic risk factors in the development of inherited thrombophilias are mutations in Factor V Leiden and Prothrombin G20210A.[1][2][3]
Please see thrombophilia classification for a list conditions associated with acquired thrombophilias, and to the page on causes of thrombophilia by organ system.
References
- ↑ Cohoon KP, Heit JA (2014). "Inherited and secondary thrombophilia". Circulation. 129 (2): 254–7. doi:10.1161/CIRCULATIONAHA.113.001943. PMC 3979345. PMID 24421360.
- ↑ Seligsohn U, Lubetsky A (2001). "Genetic susceptibility to venous thrombosis". N Engl J Med. 344 (16): 1222–31. doi:10.1056/NEJM200104193441607. PMID 11309638.
- ↑ Middeldorp S (2011). "Evidence-based approach to thrombophilia testing". J Thromb Thrombolysis. 31 (3): 275–81. doi:10.1007/s11239-011-0572-y. PMC 3056012. PMID 21340752.