Adrenoleukodystrophy overview: Difference between revisions
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{{Adrenoleukodystrophy}} | {{Adrenoleukodystrophy}} | ||
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==Overview== | ==Overview== | ||
'''Adrenoleukodystrophy''' ('''ALD''') is a degenerative disorder of [[myelin]], a complex fatty neural tissue that insulates many nerves of the [[central nervous system|central]] and [[peripheral nervous system]]s. Without myelin, [[nerve]]s are unable to conduct an impulse, leading to increasing [[disability]] as myelin destruction increases and intensifies. The victims of ALD are always male, and the disease begins its expression around the ages 5 to 10. The disease is due to an [[X-linked]] inheritance of peroxisomes that cannot properly process long chain fatty acids in the brain. | '''Adrenoleukodystrophy''' ('''ALD''') is a degenerative disorder of [[myelin]], a complex fatty neural tissue that insulates many nerves of the [[central nervous system|central]] and [[peripheral nervous system]]s. Without myelin, [[nerve]]s are unable to conduct an impulse, leading to increasing [[disability]] as myelin destruction increases and intensifies. The victims of ALD are always male, and the disease begins its expression around the ages 5 to 10. The disease is due to an [[X-linked]] inheritance of peroxisomes that cannot properly process long chain fatty acids in the brain. | ||
ALD is a type of [[leukodystrophy]], disorders affecting the growth and/or development of myelin. Leukodystrophies are different from ''demyelinating'' disorders such as [[multiple sclerosis]] where myelin is formed normally but is lost by immunologic dysfunction or for other reasons. | ALD is a type of [[leukodystrophy]], disorders affecting the growth and/or development of myelin. Leukodystrophies are different from ''demyelinating'' disorders such as [[multiple sclerosis]] where myelin is formed normally but is lost by immunologic dysfunction or for other reasons. | ||
==Historical Perspective== | |||
==Classification== | |||
==Pathophysiology== | |||
==Causes== | |||
==Differentiating Adrenoleukodystrophy from Other Diseases== | |||
==Epidemiology and Demographics== | |||
==Risk Factors== | |||
==Screening== | |||
==Natural History, Complications, and Prognosis== | |||
==Diagnosis== | |||
===Diagnostic Criteria=== | |||
===History and Symptoms=== | |||
===Physical Examination=== | |||
===Laboratory Findings=== | |||
===Imaging Findings=== | |||
===Other Diagnostic Studies=== | |||
==Treatment== | |||
===Medical Therapy=== | |||
===Surgery=== | |||
===Prevention=== | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Endocrinology]] | |||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} |
Revision as of 18:28, 22 July 2016
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Overview
Adrenoleukodystrophy (ALD) is a degenerative disorder of myelin, a complex fatty neural tissue that insulates many nerves of the central and peripheral nervous systems. Without myelin, nerves are unable to conduct an impulse, leading to increasing disability as myelin destruction increases and intensifies. The victims of ALD are always male, and the disease begins its expression around the ages 5 to 10. The disease is due to an X-linked inheritance of peroxisomes that cannot properly process long chain fatty acids in the brain.
ALD is a type of leukodystrophy, disorders affecting the growth and/or development of myelin. Leukodystrophies are different from demyelinating disorders such as multiple sclerosis where myelin is formed normally but is lost by immunologic dysfunction or for other reasons.