Thrombophilia differential diagnosis: Difference between revisions
Jump to navigation
Jump to search
mNo edit summary |
mNo edit summary |
||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
Thrombophilia is a prothrombotic state due to an underlying process. Inherited thrombophilias must be differentiated from acquired thrombophilias, as it may influence the selection and duration of [[Anticoagulant|anticoagulation]]. Inherited thrombophilias should be suspected in patients with the certain [[Thrombophilia_history_and_symptoms|clinical presentations]].<ref name="pmid24421360">{{cite journal| author=Cohoon KP, Heit JA| title=Inherited and secondary thrombophilia. | journal=Circulation | year= 2014 | volume= 129 | issue= 2 | pages= 254-7 | pmid=24421360 | doi=10.1161/CIRCULATIONAHA.113.001943 | pmc=3979345 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24421360 }} </ref><ref name="pmid11309638">{{cite journal| author=Seligsohn U, Lubetsky A| title=Genetic susceptibility to venous thrombosis. | journal=N Engl J Med | year= 2001 | volume= 344 | issue= 16 | pages= 1222-31 | pmid=11309638 | doi=10.1056/NEJM200104193441607 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11309638 | Thrombophilia is a prothrombotic state due to an underlying process. Inherited thrombophilias must be differentiated from acquired thrombophilias, as it may influence the selection and duration of [[Anticoagulant|anticoagulation]]. Inherited thrombophilias should be suspected in patients with the certain [[Thrombophilia_history_and_symptoms|clinical presentations]].<ref name="pmid24421360">{{cite journal| author=Cohoon KP, Heit JA| title=Inherited and secondary thrombophilia. | journal=Circulation | year= 2014 | volume= 129 | issue= 2 | pages= 254-7 | pmid=24421360 | doi=10.1161/CIRCULATIONAHA.113.001943 | pmc=3979345 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24421360 }} </ref><ref name="pmid11309638">{{cite journal| author=Seligsohn U, Lubetsky A| title=Genetic susceptibility to venous thrombosis. | journal=N Engl J Med | year= 2001 | volume= 344 | issue= 16 | pages= 1222-31 | pmid=11309638 | doi=10.1056/NEJM200104193441607 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11309638 }} </ref> | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Revision as of 19:33, 28 July 2016
|
Thrombophilia Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Thrombophilia differential diagnosis On the Web |
|
American Roentgen Ray Society Images of Thrombophilia differential diagnosis |
|
Risk calculators and risk factors for Thrombophilia differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Asiri Ediriwickrema, M.D., M.H.S. [2]
Overview
Thrombophilia is a prothrombotic state due to an underlying process. Inherited thrombophilias must be differentiated from acquired thrombophilias, as it may influence the selection and duration of anticoagulation. Inherited thrombophilias should be suspected in patients with the certain clinical presentations.[1][2]
Differential Diagnosis
- Thrombophilia is a prothrombotic state due to an underlying process
- Inherited thrombophilias must be differentiated from acquired thrombophilias, as it may influence the selection and duration of anticoagulation
- The most common inherited thrombophilias include Factor V Leiden and Prothrombin G20210A
- The most common acquired thrombophilic states include surgery, trauma, or prolonged immobility
- Inherited thrombophilias must be differentiated from other diseases that cause the following clinical presentations:[1][2]
- Family history of thrombosis, especially at an early age (< 45 years)
- Unprovoked thrombosis at an early age (<40-55 for venous thrombosis and <50-55 for arterial thrombosis)
- Recurrent thrombosis including Deep venous thrombosis, Pulmonary embolus, or superficial venous thrombosis
- Thrombosis at multiple sites, or unusual locations including in cerebral, hepatic, portal, mesenteric, and renal veins
- Thrombosis in arteries with the abscence of arterial disease
- History of fetal loss
- History of warfarin skin necrosis
References
- ↑ 1.0 1.1 Cohoon KP, Heit JA (2014). "Inherited and secondary thrombophilia". Circulation. 129 (2): 254–7. doi:10.1161/CIRCULATIONAHA.113.001943. PMC 3979345. PMID 24421360.
- ↑ 2.0 2.1 Seligsohn U, Lubetsky A (2001). "Genetic susceptibility to venous thrombosis". N Engl J Med. 344 (16): 1222–31. doi:10.1056/NEJM200104193441607. PMID 11309638.