Drug induced liver injury epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
Epidemiologic data on drug induced liver injury is likely an underrepresentation given the lack of active reporting and surveillance systems for drug induced liver injury worldwide.<ref name="pmid19826967">{{cite journal| author=Bell LN, Chalasani N| title=Epidemiology of idiosyncratic drug-induced liver injury. | journal=Semin Liver Dis | year= 2009 | volume= 29 | issue= 4 | pages= 337-47 | pmid=19826967 | doi=10.1055/s-0029-1240002 | pmc=2903197 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19826967 }} </ref> | |||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
===Incidence=== | ===Incidence=== | ||
===Prevalence=== | The incidence of drug induced liver injury is approximately 10 to 20 cases per 100,000 individuals worldwide.<ref name="pmid24388027">{{cite journal| author=Leise MD, Poterucha JJ, Talwalkar JA| title=Drug-induced liver injury. | journal=Mayo Clin Proc | year= 2014 | volume= 89 | issue= 1 | pages= 95-106 | pmid=24388027 | doi=10.1016/j.mayocp.2013.09.016 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24388027 }} </ref> | ||
===Case Mortality Rate=== | ===Prevalence=== | ||
The prevalence of drug induced liver injury is estimated to be 44,000 cases annually. It is the most common cause of acute liver failure in the United States, representing 13% of total cases. However, drug induced liver injury accounts for only a small proportion of all idiosyncratic adverse drug reactions.<ref name="pmid19826967">{{cite journal| author=Bell LN, Chalasani N| title=Epidemiology of idiosyncratic drug-induced liver injury. | journal=Semin Liver Dis | year= 2009 | volume= 29 | issue= 4 | pages= 337-47 | pmid=19826967 | doi=10.1055/s-0029-1240002 | pmc=2903197 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19826967 }} </ref> | |||
===Case Mortality Rate=== | |||
The case-fatality rate of drug induced liver injury is approximately 10 to 50%, depending on the inciting drug. Registries from the United States, Spain, and Sweden specifically have demonstrated 9-12% mortality rate.[http://www.medscape.com/viewarticle/711396] | |||
===Age=== | ===Age=== | ||
Patients of all age groups may develop drug induced liver injury. | |||
===Gender=== | ===Gender=== | ||
Due to the higher proportion of females in many retrospective and prospective cohorts of drug induced liver injury, it was thought that females are more commonly affected than males.<ref name="pmid11951073">{{cite journal| author=Hartleb M, Biernat L, Kochel A| title=Drug-induced liver damage -- a three-year study of patients from one gastroenterological department. | journal=Med Sci Monit | year= 2002 | volume= 8 | issue= 4 | pages= CR292-6 | pmid=11951073 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11951073 }} </ref> However, more recent reviews have demonstrated that drug induced liver injury affects men and women equally.<ref name="pmid18955056">{{cite journal| author=Chalasani N, Fontana RJ, Bonkovsky HL, Watkins PB, Davern T, Serrano J et al.| title=Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. | journal=Gastroenterology | year= 2008 | volume= 135 | issue= 6 | pages= 1924-34, 1934.e1-4 | pmid=18955056 | doi=10.1053/j.gastro.2008.09.011 | pmc=3654244 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18955056 }} </ref> | |||
===Race=== | ===Race=== | ||
There is no racial predilection to drug induced liver injury. | |||
==References== | ==References== | ||
{{Reflist | {{Reflist}} | ||
[[Category:Hepatology]] | [[Category:Hepatology]] | ||
Revision as of 21:51, 2 August 2016
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Drug induced liver injury Microchapters |
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Differentiating Drug Induced Liver Injury from other Diseases |
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Diagnosis |
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Case Studies |
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Drug Induced Liver Injury On the Web |
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American Roentgen Ray Society Images of Drug induced liver injury |
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Risk calculators and risk factors for Drug induced liver injury |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:
Overview
Epidemiologic data on drug induced liver injury is likely an underrepresentation given the lack of active reporting and surveillance systems for drug induced liver injury worldwide.[1]
Epidemiology and Demographics
Incidence
The incidence of drug induced liver injury is approximately 10 to 20 cases per 100,000 individuals worldwide.[2]
Prevalence
The prevalence of drug induced liver injury is estimated to be 44,000 cases annually. It is the most common cause of acute liver failure in the United States, representing 13% of total cases. However, drug induced liver injury accounts for only a small proportion of all idiosyncratic adverse drug reactions.[1]
Case Mortality Rate
The case-fatality rate of drug induced liver injury is approximately 10 to 50%, depending on the inciting drug. Registries from the United States, Spain, and Sweden specifically have demonstrated 9-12% mortality rate.[2]
Age
Patients of all age groups may develop drug induced liver injury.
Gender
Due to the higher proportion of females in many retrospective and prospective cohorts of drug induced liver injury, it was thought that females are more commonly affected than males.[3] However, more recent reviews have demonstrated that drug induced liver injury affects men and women equally.[4]
Race
There is no racial predilection to drug induced liver injury.
References
- ↑ 1.0 1.1 Bell LN, Chalasani N (2009). "Epidemiology of idiosyncratic drug-induced liver injury". Semin Liver Dis. 29 (4): 337–47. doi:10.1055/s-0029-1240002. PMC 2903197. PMID 19826967.
- ↑ Leise MD, Poterucha JJ, Talwalkar JA (2014). "Drug-induced liver injury". Mayo Clin Proc. 89 (1): 95–106. doi:10.1016/j.mayocp.2013.09.016. PMID 24388027.
- ↑ Hartleb M, Biernat L, Kochel A (2002). "Drug-induced liver damage -- a three-year study of patients from one gastroenterological department". Med Sci Monit. 8 (4): CR292–6. PMID 11951073.
- ↑ Chalasani N, Fontana RJ, Bonkovsky HL, Watkins PB, Davern T, Serrano J; et al. (2008). "Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States". Gastroenterology. 135 (6): 1924–34, 1934.e1–4. doi:10.1053/j.gastro.2008.09.011. PMC 3654244. PMID 18955056.