Typhoid fever pathophysiology: Difference between revisions
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== | == Genetics == | ||
Typhoid fever may be associtated with genes of the Class II and Class III Major Histocompatibility Complex.<ref>Dunstan, Sarah J., et al. "Genes of the class II and class III major histocompatibility complex are associated with typhoid fever in Vietnam." Journal of Infectious Diseases 183.2 (2001): 261-268.</ref> | |||
Two types of HLA associations can be found with typhoid fever:<ref name="pmid12456854">{{cite journal| author=Parry CM, Hien TT, Dougan G, White NJ, Farrar JJ| title=Typhoid fever. | journal=N Engl J Med | year= 2002 | volume= 347 | issue= 22 | pages= 1770-82 | pmid=12456854 | doi=10.1056/NEJMra020201 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12456854 }} </ref> | |||
*HLA-DRB1*0301/6/8, HLA-DQB1*0201-3, and TNFA*2(–308) associated with increased susceptibility to typhoid fever. | |||
*HLA-DRB1*04, HLA-DQB1*0401/2, and TNFA*1(–308)associated with increased disease resistance. | |||
== References == | == References == | ||
Revision as of 21:51, 30 August 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Genetics
Typhoid fever may be associtated with genes of the Class II and Class III Major Histocompatibility Complex.[1] Two types of HLA associations can be found with typhoid fever:[2]
- HLA-DRB1*0301/6/8, HLA-DQB1*0201-3, and TNFA*2(–308) associated with increased susceptibility to typhoid fever.
- HLA-DRB1*04, HLA-DQB1*0401/2, and TNFA*1(–308)associated with increased disease resistance.
References
- ↑ Dunstan, Sarah J., et al. "Genes of the class II and class III major histocompatibility complex are associated with typhoid fever in Vietnam." Journal of Infectious Diseases 183.2 (2001): 261-268.
- ↑ Parry CM, Hien TT, Dougan G, White NJ, Farrar JJ (2002). "Typhoid fever". N Engl J Med. 347 (22): 1770–82. doi:10.1056/NEJMra020201. PMID 12456854.