Aphthous ulcer pathophysiology: Difference between revisions
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The exact pathogenesis of aphthous ulcer in not clear. | The exact pathogenesis of aphthous ulcer in not clear. | ||
Contributing factors include: | Contributing factors include: | ||
*Allergies | *[[Allergies]] | ||
*Genetic predisposition | *Genetic predisposition | ||
*Hormonal influences | *[[Hormonal influences]] | ||
*Hematologic abnormalities | *[[Hematologic abnormalities]] | ||
*Immunologic factors | *Immunologic factors | ||
*Infectious agents | *Infectious agents | ||
*Nutritional deficiencies | *[[Nutritional deficiencies]] | ||
*Smoking cessation | *Smoking cessation | ||
*Stress | *Stress | ||
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**[[Crohn disease]] | **[[Crohn disease]] | ||
**[[Ulcerative colitis]] | **[[Ulcerative colitis]] | ||
**[[Human immunodeficiency virus | **[[Human immunodeficiency virus]] infection | ||
**Periodic fever, aphthosis, pharyngitis, and adenitis (PFAPA) or [[Marshall syndrome]] | **Periodic fever, aphthosis, pharyngitis, and adenitis (PFAPA) or [[Marshall syndrome]] | ||
**[[Cyclic neutropenia]] | **[[Cyclic neutropenia]] | ||
| Line 37: | Line 37: | ||
*Genetics | *Genetics | ||
**Ethnicity | **Ethnicity | ||
**[[HLA|Human leukocyte antigen haplotypes]] (HLA B51 | **[[HLA|Human leukocyte antigen haplotypes]] (HLA B51) | ||
*Allergic/Immunologic | *Allergic/Immunologic | ||
**Local T-lymphocyte cytotoxicity | **Local [[Cytotoxic T cell|T-lymphocyte cytotoxicity]] | ||
**Sodium lauryl sulfate sensitivity (in tooth paste) | **Sodium lauryl sulfate sensitivity (in tooth paste) | ||
**Abnormal CD4 | **[[Helper/suppressor ratio|Abnormal CD4/CD8 ratio]] | ||
**Microbe-induced hypersensitivity | **Microbe-induced hypersensitivity | ||
**Food sensitivity | **Food sensitivity | ||
*Others | *Others | ||
**[[Antioxidants]] | **[[Antioxidants]] | ||
**[[ | **[[Non steroidal anti inflammatory drugs (NSAIDs)]] | ||
**[[ | **[[Beta blockers]] | ||
**[[Immunosuppressive]] | **[[Immunosuppressive drugs]] | ||
**Stress | **Stress | ||
**Psychological imbalance | **Psychological imbalance | ||
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==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 13:31, 6 September 2016
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Aphthous ulcer Microchapters |
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Aphthous ulcer pathophysiology On the Web |
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American Roentgen Ray Society Images of Aphthous ulcer pathophysiology |
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Risk calculators and risk factors for Aphthous ulcer pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mehrsefat, M.D. [2]
Overview
The pathophysiology of Aphthous ulcers is not fully understood. It is though that reucurren
Pathophysiology
Pathogenesis
The exact pathogenesis of aphthous ulcer in not clear. Contributing factors include:
- Allergies
- Genetic predisposition
- Hormonal influences
- Hematologic abnormalities
- Immunologic factors
- Infectious agents
- Nutritional deficiencies
- Smoking cessation
- Stress
- Trauma
It is thought that aphthous ulcer is the result of the cross reactivity between Staphylococcus sanguis and 60kDa Heat shock protein (HSP60)
It is thought aphthous ulcer is a result of is caused by either , [hypothesis 2], or [hypothesis 3].
Associated conditions
- Systemic disease
- Behcet disease
- Mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome
- Crohn disease
- Ulcerative colitis
- Human immunodeficiency virus infection
- Periodic fever, aphthosis, pharyngitis, and adenitis (PFAPA) or Marshall syndrome
- Cyclic neutropenia
- Microbial
- Bacterial (streptococci)
- Viral (varicella zoster and cytomegalovirus)
- Genetics
- Ethnicity
- Human leukocyte antigen haplotypes (HLA B51)
- Allergic/Immunologic
- Local T-lymphocyte cytotoxicity
- Sodium lauryl sulfate sensitivity (in tooth paste)
- Abnormal CD4/CD8 ratio
- Microbe-induced hypersensitivity
- Food sensitivity
- Others
- Antioxidants
- Non steroidal anti inflammatory drugs (NSAIDs)
- Beta blockers
- Immunosuppressive drugs
- Stress
- Psychological imbalance