Hepatitis B screening: Difference between revisions
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**(HBsAg) test followed by a licensed, neutralizing confirmatory test | **(HBsAg) test followed by a licensed, neutralizing confirmatory test | ||
**Testing for antibodies to HBsAg (anti-HBs) and hepatitis B core antigen (anti-HBc) (distinguish between infection and immunity) | **Testing for antibodies to HBsAg (anti-HBs) and hepatitis B core antigen (anti-HBc) (distinguish between infection and immunity) | ||
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== References == | == References == | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Infectious disease]] | [[Category:Infectious disease]] | ||
[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} |
Revision as of 21:02, 10 October 2016
Hepatitis B |
Diagnosis |
Treatment |
Case Studies |
Hepatitis B screening On the Web |
American Roentgen Ray Society Images of Hepatitis B screening |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
High risk groups should be tested for HBV infection. These include immigrants/refugees from areas of intermediate or high endemicity, persons with chronically elevated aminotransferases, immunocompromised individuals, and persons with a history of injection drug use(IDU).
Screening for hepatocellular carcinoma should extend to Asian men over 40 years and Asian women over 50 years of age, persons with cirrhosis, persons with a family history of HCC, Africans over 20 years of age, and any HBV carrier over 40 years with persistent or intermittent ALT elevation and/or high HBV DNA level >2,000 IU/mL.
Screening
Recommendations for Persons Who Should Be Tested for HBV Infection: AASLD Practice Guidelines 2009
The following groups should be tested for HBV infection:[1]
- Persons born in high or intermediate endemic areas
- United States– born persons not vaccinated as infants whose parents were born in regions with high HBV endemicity]
- Persons with chronically elevated aminotransferases
- Persons needing immunosuppressive therapy
- Men who have sex with men
- Persons with multiple sexual partners or history of sexually transmitted disease
- Inmates of correctional facilities
- Persons who have ever used injecting drugs, dialysis patients, HIV or HCV infected individuals, pregnant women, and family members, household members, and sexual contacts of HBV infected persons.
- Testing for HBsAg and anti-HBs should be performed, and seronegative persons should be vaccinated. (Grade I Recommendation)}}
Recommendations for HCC Screening: AASLD Practice Guidelines 2009
The following groups should be screened with US examination every 6-12 months: (Grade II-2)[1]
- HBV carriers at high risk for HCC such as Asian men over 40 years and Asian women over 50 years of age
- Persons with cirrhosis
- Persons with a family history of HCC
- Africans over 20 years of age
- Any carrier over 40 years with persistent or intermittent ALT elevation and/or high HBV DNA level >2,000 IU/mL
For HBV carriers at high risk for HCC who are living in areas where US is not readily available, periodic screening with AFP should be considered. (Grade II-2)}}
Group | Screening Recommendations |
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Pregnant women |
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Asymptomatic/Nonpregnant adolescents and adults at high risk (HBV) |
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References
- ↑ 1.0 1.1 Lok AS, McMahon BJ (2004). "[AASLD Practice Guidelines. Chronic hepatitis B: update of therapeutic guidelines]" (PDF). Romanian Journal of Gastroenterology. 13 (2): 150–4. PMID 15229781. Retrieved 2012-02-10. Unknown parameter
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