Drug induced liver injury laboratory findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Drug induced liver injury}} | {{Drug induced liver injury}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{Rachita}} | ||
==Overview== | ==Overview== | ||
Laboratory finding reflects whether the liver injury is more hepatocellular or cholestatic in nature. | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
The following laboratory tests should be obtained to assess the severity of illness as well as distinguish drug induced liver injury from other pathologies: | |||
* [[CBC]] with differential: may reveal eosinophilia in hypersensitivity reactions, or lymphocytosis (with atypical lymphocytes on smear) in mononucleosis-like illnesses | |||
* [[Alkaline phosphatase]]: will be disproportionately elevated compared to aminotransferases below in cholestatic injury | |||
* [[AST]] / [[serum glutamic oxaloacetic transaminase]] ([[SGOT]]): can be markedly elevated (> 20 times the upper limit of normal) in cases of acute hepatocellular injury | |||
* [[ALT]] / [[serum glutamic pyruvate transaminase]] ([[SGPT]]): can be markedly elevated (> 20 times the upper limit of normal) in cases of acute hepatocellular injury | |||
* [[Albumin]]: will be low in chronic liver injury | |||
* [[Bilirubin]]: may be elevated in both hepatocellular and cholestatic injury | |||
* [[Prothrombin time]], particularly after administration of [[vitamin K]] | |||
* [[Anti-mitochondrial antibody]] ([[AMA]]) to distinguish from [[autoimmune hepatitis]] | |||
* [[Anti smooth muscle antibody]] ([[ASMA]]) to distinguish from [[autoimmune hepatitis]] | |||
* [[Urinalysis]] to assess bilirubinuria | |||
* Drug levels, e.g. acetaminophen serum level | |||
==References== | ==References== | ||
Revision as of 20:35, 19 October 2016
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Drug induced liver injury Microchapters |
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Differentiating Drug Induced Liver Injury from other Diseases |
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Drug Induced Liver Injury On the Web |
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American Roentgen Ray Society Images of Drug induced liver injury |
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Risk calculators and risk factors for Drug induced liver injury |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rachita Navara, M.D. [2]
Overview
Laboratory finding reflects whether the liver injury is more hepatocellular or cholestatic in nature.
Laboratory Findings
The following laboratory tests should be obtained to assess the severity of illness as well as distinguish drug induced liver injury from other pathologies:
- CBC with differential: may reveal eosinophilia in hypersensitivity reactions, or lymphocytosis (with atypical lymphocytes on smear) in mononucleosis-like illnesses
- Alkaline phosphatase: will be disproportionately elevated compared to aminotransferases below in cholestatic injury
- AST / serum glutamic oxaloacetic transaminase (SGOT): can be markedly elevated (> 20 times the upper limit of normal) in cases of acute hepatocellular injury
- ALT / serum glutamic pyruvate transaminase (SGPT): can be markedly elevated (> 20 times the upper limit of normal) in cases of acute hepatocellular injury
- Albumin: will be low in chronic liver injury
- Bilirubin: may be elevated in both hepatocellular and cholestatic injury
- Prothrombin time, particularly after administration of vitamin K
- Anti-mitochondrial antibody (AMA) to distinguish from autoimmune hepatitis
- Anti smooth muscle antibody (ASMA) to distinguish from autoimmune hepatitis
- Urinalysis to assess bilirubinuria
- Drug levels, e.g. acetaminophen serum level