Myoglobinuria: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
Under ideal situations myoglobin will be filtered and excreted with the urine, but if too much myoglobin is released into the circulation or in case of renal problems, it can occlude the renal filtration system leading to acute tubular necrosis and acute [[renal insufficiency]]. | Under ideal situations myoglobin will be filtered and excreted with the urine, but if too much myoglobin is released into the circulation or in case of renal problems, it can occlude the renal filtration system leading to acute tubular necrosis and acute [[renal insufficiency]]. | ||
==Causes== | |||
===Causes by Organ System=== | |||
===Causes in Alphabetical Order=== | |||
==Differential diagnosis of causes of myoglobinuria== | ==Differential diagnosis of causes of myoglobinuria== | ||
[[Physical trauma|Trauma]], vascular problems, [[venom]]s, certain drugs and other situations can destroy or damage the muscle, releasing myoglobin to the circulation and thus to the kidneys. | [[Physical trauma|Trauma]], vascular problems, [[venom]]s, certain drugs and other situations can destroy or damage the muscle, releasing myoglobin to the circulation and thus to the kidneys. | ||
Revision as of 15:31, 7 November 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Myoglobinuria is the presence of myoglobin in the urine, usually associated with rhabdomyolysis or muscle destruction. Myoglobin is present in muscle cells as a reserve of oxygen.
Pathophysiology
Under ideal situations myoglobin will be filtered and excreted with the urine, but if too much myoglobin is released into the circulation or in case of renal problems, it can occlude the renal filtration system leading to acute tubular necrosis and acute renal insufficiency.
Causes
Causes by Organ System
Causes in Alphabetical Order
Differential diagnosis of causes of myoglobinuria
Trauma, vascular problems, venoms, certain drugs and other situations can destroy or damage the muscle, releasing myoglobin to the circulation and thus to the kidneys.
Miscellaneous syndromes
- Rhabdomyolysis
- Meyer-Betz disease
Autosomal recessive conditions
- Glycogenosis type 5
- Phosphogylcerate mutase 2 deficiency
Cardiac and vascular conditions
Inflammatory conditions
Trauma, mechanical and physical conditions
Differentiating myoglobinuria from hemoglobinuria
After centrifuge, the serum of myologinuria is clear, where the serum of hemoglobinuria after centrifuge is pink.
External Links
- Overview at wustl.edu