Granulomatosis with polyangiitis history and symptoms: Difference between revisions
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The initial common signs that are present in patients with Granulomatosis with polyangiitis are non-specific in nature. The following are signs and symptoms of Granulomatosis with polyangiitis:<ref name="pmid6336643">{{cite journal| author=Fauci AS, Haynes BF, Katz P, Wolff SM| title=Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. | journal=Ann Intern Med | year= 1983 | volume= 98 | issue= 1 | pages= 76-85 | pmid=6336643 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6336643 }} </ref> | The initial common signs that are present in patients with Granulomatosis with polyangiitis are non-specific in nature. The following are signs and symptoms of Granulomatosis with polyangiitis:<ref name="pmid6336643">{{cite journal| author=Fauci AS, Haynes BF, Katz P, Wolff SM| title=Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. | journal=Ann Intern Med | year= 1983 | volume= 98 | issue= 1 | pages= 76-85 | pmid=6336643 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6336643 }} </ref> | ||
<ref name="pmid27733943">{{cite journal| author=Pagnoux C| title=Updates in ANCA-associated vasculitis. | journal=Eur J Rheumatol | year= 2016 | volume= 3 | issue= 3 | pages= 122-133 | pmid=27733943 | doi=10.5152/eurjrheum.2015.0043 | pmc=5058451 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27733943 }} </ref> | <ref name="pmid27733943">{{cite journal| author=Pagnoux C| title=Updates in ANCA-associated vasculitis. | journal=Eur J Rheumatol | year= 2016 | volume= 3 | issue= 3 | pages= 122-133 | pmid=27733943 | doi=10.5152/eurjrheum.2015.0043 | pmc=5058451 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27733943 }} </ref> | ||
===Constitutional Symptoms=== | |||
* malaise | * malaise | ||
* pyrexia | * pyrexia | ||
Revision as of 17:16, 7 November 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
Obtaining a complete history is an important aspect in making a clinical diagnosis of Granulomatosis with polyangiitis. As it can help aid in differentiating between the ANCA associated vacuities and other possible causes that may mimic the disease.There are many similarities that are present between ANCA associated vacuities and Granulomatosis with polyangiitis. A history and physical can help assess the disease.
Symptoms
Obtaining a complete history is an important aspect in making a clinical diagnosis of Granulomatosis with polyangiitis. As it can help aid in differentiating between the ANCA associated vacuities and other possible causes that may mimic the disease. There are many similarities that are present between ANCA associated vacuities and Granulomatosis with polyangiitis. A history and physical can assess the disease. The initial common signs that are present in patients with Granulomatosis with polyangiitis are non-specific in nature. The following are signs and symptoms of Granulomatosis with polyangiitis:[1] [2]
Constitutional Symptoms
- malaise
- pyrexia
- weight loss
- arthralgia
- cough
- dyspnea
- purpura
- abnormal urinary sediment
Ear, nose and throat involvement:
- nasal crusting
- sinusitis
- otitis media
- otorrhea
- epistaxis
- ulcers of the oral cavity or nasal
- conductive and or sensorineural hearing loss
- saddle nose deformity
- masses present in the upper airway
- cranial nerve entrapment
Pulmonary involvement:
- hoarseness
- cough
- dyspnea
- stridor
- hemoptysis
- pulmonary fibrosis
- pulmonary arterial hypertension
- parenchymal lung nodules
Renal involvement:
- glomerulonephritis
- hematuria
- rise in serum creatinine
- edema
- hypertension
- red cell cast
Cutaneous involvement:
- leukocytoclastic angiitis
- livedo reticularis
Ophthalmic involvement:
- conjunctivitis
- ulceration of the cornea
- episcleritis
Nervous system involvement:
- mononeuritis multiplex
- sensory neuropathy
- sensorineural hearing loss
- pachymeningitis
A diagnosis of Granulomatosis with polyangiitis can be made when three out of the six criteria are established. They are:[3]
- a histopathology that shows granuloma
- the upper respiratory tract is involved
- there is a stenosis that is present in larynx, trachea, and the bronchioles
- the pulmonary system is involved
- the presence of anti-neutrophil cytoplasmic antibodies
- the presence of glomerulonephritis
References
- ↑ Fauci AS, Haynes BF, Katz P, Wolff SM (1983). "Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years". Ann Intern Med. 98 (1): 76–85. PMID 6336643.
- ↑ Pagnoux C (2016). "Updates in ANCA-associated vasculitis". Eur J Rheumatol. 3 (3): 122–133. doi:10.5152/eurjrheum.2015.0043. PMC 5058451. PMID 27733943.
- ↑ Noone D, Hebert D, Licht C (2016). "Pathogenesis and treatment of ANCA-associated vasculitis-a role for complement". Pediatr Nephrol. ( ): . doi:10.1007/s00467-016-3475-5. PMID 27596099.