Granulomatosis with polyangiitis laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of Granulomatosis with polyangiitis include, anti-neutrophil cytoplasmic antibody, elevated blood urea nitrogen, elevated creatinine serum, erythrocyte sedimentation rate, C reactive protein, proteinuria, microscopic hematuria, and red blood casts. | |||
==Work-Up== | ==Work-Up== | ||
===Blood Work-Up=== | ===Blood Work-Up=== | ||
Revision as of 16:49, 9 November 2016
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Granulomatosis with polyangiitis Microchapters |
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Differentiating Granulomatosis with polyangiitis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]
Overview
Laboratory findings consistent with the diagnosis of Granulomatosis with polyangiitis include, anti-neutrophil cytoplasmic antibody, elevated blood urea nitrogen, elevated creatinine serum, erythrocyte sedimentation rate, C reactive protein, proteinuria, microscopic hematuria, and red blood casts.
Work-Up
Blood Work-Up
Urianlysis
Renal Biopsy
Renal biopsy is the gold standard in establishing Granulomatosis with polyangiitis.[1] Renal biopsy reveals under electron microscopy subendothelial edema, microthrombosis, and degranulation of neutrophils. Under light microscopy, necrotizing and crescentic glomerulonephritis is seen. [2]
References
- ↑ Berden AE, Ferrario F, Hagen EC, Jayne DR, Jennette JC, Joh K; et al. (2010). "Histopathologic classification of ANCA-associated glomerulonephritis". J Am Soc Nephrol. 21 (10): 1628–36. doi:10.1681/ASN.2010050477. PMID 20616173.
- ↑ Bajema IM, Hagen EC, Ferrario F, de Heer E, Bruijn JA (2001). "Immunopathological aspects of systemic vasculitis". Springer Semin Immunopathol. 23 (3): 253–65. PMID 11591101.