Churg-Strauss syndrome causes: Difference between revisions
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==Causes== | ==Causes== | ||
Currently there are no established causes for Eosinophilic granulomatosis with polyangiitis. However, it has been hypothesized that factors such as environmental, immunological, and genetic play a role in the development of the disease. | Currently there are no established causes for Eosinophilic granulomatosis with polyangiitis. However, it has been hypothesized that factors such as environmental, immunological, and genetic play a role in the development of the disease. | ||
It has also been hypothesized that patient using leukotriene antagonist for the treatment of asthma have developed Eosinophilic granulomatosis with polyangiitis. However, there is not enough evidence to support this claim. It has been more likely associated with the tapering of glucocorticoids in patients who have Eosinophilic granulomatosis with polyangiitis that is not clinically evident until glucocorticoids are tapered. However, this distinction needs to differentiated from idiopathic asthma and early forms of Eosinophilic granulomatosis with polyangiitis. One way by which this can be done, is by clinical presentation. Patients who present with severe upper airway disease, such as sinusitis, that shows an abnormal paranasal through radiography is more likely to be an early sign of Eosinophilic granulomatosis with polyangiitis rather than idiopathic asthma.<ref name="pmid21810082">{{cite journal| author=Luo QZ, Lin L, Gong Z, Mei B, Xu YJ, Huo Z et al.| title=Positive association of major histocompatibility complex class I chain-related gene A polymorphism with leukemia susceptibility in the people of Han nationality of Southern China. | journal=Tissue Antigens | year= 2011 | volume= 78 | issue= 3 | pages= 178-84 | pmid=21810082 | doi=10.1111/j.1399-0039.2011.01748.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21810082 }} </ref> | It has also been hypothesized that patient using leukotriene antagonist for the treatment of asthma have developed Eosinophilic granulomatosis with polyangiitis. However, there is not enough evidence to support this claim. It has been more likely associated with the tapering of glucocorticoids in patients who have Eosinophilic granulomatosis with polyangiitis that is not clinically evident until glucocorticoids are tapered. However, this distinction needs to differentiated from idiopathic asthma and early forms of Eosinophilic granulomatosis with polyangiitis. One way by which this can be done, is by clinical presentation. Patients who present with severe upper airway disease, such as sinusitis, that shows an abnormal paranasal through radiography is more likely to be an early sign of Eosinophilic granulomatosis with polyangiitis rather than idiopathic asthma.<ref name="pmid21810082">{{cite journal| author=Luo QZ, Lin L, Gong Z, Mei B, Xu YJ, Huo Z et al.| title=Positive association of major histocompatibility complex class I chain-related gene A polymorphism with leukemia susceptibility in the people of Han nationality of Southern China. | journal=Tissue Antigens | year= 2011 | volume= 78 | issue= 3 | pages= 178-84 | pmid=21810082 | doi=10.1111/j.1399-0039.2011.01748.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21810082 }} </ref> | ||
Revision as of 13:54, 21 November 2016
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Overview
Currently there are no established causes for Eosinophilic granulomatosis with polyangiitis. However, it has been hypothesized that factors such as environmental, immunological, and genetic play a role in the development of the disease.
Causes
Currently there are no established causes for Eosinophilic granulomatosis with polyangiitis. However, it has been hypothesized that factors such as environmental, immunological, and genetic play a role in the development of the disease.
It has also been hypothesized that patient using leukotriene antagonist for the treatment of asthma have developed Eosinophilic granulomatosis with polyangiitis. However, there is not enough evidence to support this claim. It has been more likely associated with the tapering of glucocorticoids in patients who have Eosinophilic granulomatosis with polyangiitis that is not clinically evident until glucocorticoids are tapered. However, this distinction needs to differentiated from idiopathic asthma and early forms of Eosinophilic granulomatosis with polyangiitis. One way by which this can be done, is by clinical presentation. Patients who present with severe upper airway disease, such as sinusitis, that shows an abnormal paranasal through radiography is more likely to be an early sign of Eosinophilic granulomatosis with polyangiitis rather than idiopathic asthma.[1]
References
- ↑ Luo QZ, Lin L, Gong Z, Mei B, Xu YJ, Huo Z; et al. (2011). "Positive association of major histocompatibility complex class I chain-related gene A polymorphism with leukemia susceptibility in the people of Han nationality of Southern China". Tissue Antigens. 78 (3): 178–84. doi:10.1111/j.1399-0039.2011.01748.x. PMID 21810082.