Acute pancreatitis epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
The annual incidence of acute pancreatitis in the U.S. is 18 to 49 per 100,000 population.<ref name="pmid18362258">{{cite journal| author=Yang AL, Vadhavkar S, Singh G, Omary MB| title=Epidemiology of alcohol-related liver and pancreatic disease in the United States. | journal=Arch Intern Med | year= 2008 | volume= 168 | issue= 6 | pages= 649-56 | pmid=18362258 | doi=10.1001/archinte.168.6.649 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18362258 }}</ref> In several European studies, the incidence of acute pancreatitis is reported at 12.4 to 31.2 per 100,000.<ref>{{cite journal |author=Eland IA, Sturkenboom MJ, Wilson JH, Stricker BH |title=Incidence and mortality of acute pancreatitis between 1985 and 1995 |journal=Scand. J. Gastroenterol. |volume=35 |issue=10 |pages=1110-6 |year=2000 |pmid=11099067 |doi=}}</ref><ref>{{cite journal |author=Goldacre MJ, Roberts SE |title=Hospital admission for acute pancreatitis in an English population, 1963-98: database study of incidence and mortality |journal=BMJ |volume=328 |issue=7454 |pages=1466-9 |year=2004 |pmid=15205290 |doi=10.1136/bmj.328.7454.1466}}</ref> A consistent increase in incidence of pancreatitis has been reported in different geographical regions.<ref name="pmid15354285">{{cite journal| author=Lindkvist B, Appelros S, Manjer J, Borgström A| title=Trends in incidence of acute pancreatitis in a Swedish population: is there really an increase? | journal=Clin Gastroenterol Hepatol | year= 2004 | volume= 2 | issue= 9 | pages= 831-7 | pmid=15354285 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15354285 }}</ref> | The annual incidence of acute pancreatitis in the U.S. is 18 to 49 per 100,000 population.<ref name="pmid18362258">{{cite journal| author=Yang AL, Vadhavkar S, Singh G, Omary MB| title=Epidemiology of alcohol-related liver and pancreatic disease in the United States. | journal=Arch Intern Med | year= 2008 | volume= 168 | issue= 6 | pages= 649-56 | pmid=18362258 | doi=10.1001/archinte.168.6.649 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18362258 }}</ref> In several European studies, the incidence of acute pancreatitis is reported at 12.4 to 31.2 per 100,000.<ref>{{cite journal |author=Eland IA, Sturkenboom MJ, Wilson JH, Stricker BH |title=Incidence and mortality of acute pancreatitis between 1985 and 1995 |journal=Scand. J. Gastroenterol. |volume=35 |issue=10 |pages=1110-6 |year=2000 |pmid=11099067 |doi=}}</ref><ref>{{cite journal |author=Goldacre MJ, Roberts SE |title=Hospital admission for acute pancreatitis in an English population, 1963-98: database study of incidence and mortality |journal=BMJ |volume=328 |issue=7454 |pages=1466-9 |year=2004 |pmid=15205290 |doi=10.1136/bmj.328.7454.1466}}</ref> A consistent increase in incidence of pancreatitis has been reported in different geographical regions.<ref name="pmid15354285">{{cite journal| author=Lindkvist B, Appelros S, Manjer J, Borgström A| title=Trends in incidence of acute pancreatitis in a Swedish population: is there really an increase? | journal=Clin Gastroenterol Hepatol | year= 2004 | volume= 2 | issue= 9 | pages= 831-7 | pmid=15354285 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15354285 }}</ref><ref name="pmid22205468">{{cite journal| author=Yadav D, Muddana V, O'Connell M| title=Hospitalizations for chronic pancreatitis in Allegheny County, Pennsylvania, USA. | journal=Pancreatology | year= 2011 | volume= 11 | issue= 6 | pages= 546-52 | pmid=22205468 | doi=10.1159/000331498 | pmc=3270812 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22205468 }} </ref> | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
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Overview
The annual incidence of acute pancreatitis in the U.S. is 18 to 49 per 100,000 population.[1] In several European studies, the incidence of acute pancreatitis is reported at 12.4 to 31.2 per 100,000.[2][3] A consistent increase in incidence of pancreatitis has been reported in different geographical regions.[4][5]
Epidemiology and Demographics
Incidence
The incidence of acute pancreatitis is variable and fluctuates between 12.4 to 31.2 per 100,000 depending on the population and time period studied. More importantly, is a consistent trend of increasing incidence across different studies.[4][6] [7][5]
A UK study reports an increased incidence from the mid-1990s to 2013, in both males and females from ~14.5 to ~30 per 100,000. [8]
The reason for this increased incidence is not clearly understood with some reporting an increase in alcoholic pancreatitis, while others report a decrease in this etiology. An increase in gallstone and gallbladder associated conditions has been reported.
Mortality
The mortality associated with acute pancreatitis has decreased significantly over the years with the improvements in medical care. Currently the mortality is about ~2%. This figure increases depending on the subgroup studied. Subgroups associated with a higher mortality include the elderly, the morbidly obese, and patients who acquire hospital infections. Mortality has been reported as high as 30% in some patient groups.
Age
Gender
Acute pancreatitis affects both men and women. Most studies report a slightly higher incidence in men than women.
Race
Blacks carry a 2-3 fold risk of developing pancreatitis than other races [7][5]
References
- ↑ Yang AL, Vadhavkar S, Singh G, Omary MB (2008). "Epidemiology of alcohol-related liver and pancreatic disease in the United States". Arch Intern Med. 168 (6): 649–56. doi:10.1001/archinte.168.6.649. PMID 18362258.
- ↑ Eland IA, Sturkenboom MJ, Wilson JH, Stricker BH (2000). "Incidence and mortality of acute pancreatitis between 1985 and 1995". Scand. J. Gastroenterol. 35 (10): 1110–6. PMID 11099067.
- ↑ Goldacre MJ, Roberts SE (2004). "Hospital admission for acute pancreatitis in an English population, 1963-98: database study of incidence and mortality". BMJ. 328 (7454): 1466–9. doi:10.1136/bmj.328.7454.1466. PMID 15205290.
- ↑ 4.0 4.1 Lindkvist B, Appelros S, Manjer J, Borgström A (2004). "Trends in incidence of acute pancreatitis in a Swedish population: is there really an increase?". Clin Gastroenterol Hepatol. 2 (9): 831–7. PMID 15354285.
- ↑ 5.0 5.1 5.2 Yadav D, Muddana V, O'Connell M (2011). "Hospitalizations for chronic pancreatitis in Allegheny County, Pennsylvania, USA". Pancreatology. 11 (6): 546–52. doi:10.1159/000331498. PMC 3270812. PMID 22205468.
- ↑ Yadav D, Lowenfels AB (2013). "The epidemiology of pancreatitis and pancreatic cancer". Gastroenterology. 144 (6): 1252–61. doi:10.1053/j.gastro.2013.01.068. PMC 3662544. PMID 23622135.
- ↑ 7.0 7.1 Yadav D, Lowenfels AB (2013). "The epidemiology of pancreatitis and pancreatic cancer". Gastroenterology. 144 (6): 1252–61. doi:10.1053/j.gastro.2013.01.068. PMC 3662544. PMID 23622135.
- ↑ Hazra N, Gulliford M (2014). "Evaluating pancreatitis in primary care: a population-based cohort study". Br J Gen Pract. 64 (622): e295–301. doi:10.3399/bjgp14X679732. PMC 4001169. PMID 24771844.