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==Risk Factors==
==Risk Factors==
Risk factors of diabetic nephropathy can be subcategorized into modifiable and non-modifiable risk factors:
===Modifiable Risk Factors===
Modifiable risk factors include:<ref name="pmid25342915">{{cite journal |vauthors=Lim AKh |title=Diabetic nephropathy - complications and treatment |journal=Int J Nephrol Renovasc Dis |volume=7 |issue= |pages=361–81 |year=2014 |pmid=25342915 |pmc=4206379 |doi=10.2147/IJNRD.S40172 |url=}}</ref><ref name="pmid26676664">{{cite journal |vauthors=Tziomalos K, Athyros VG |title=Diabetic Nephropathy: New Risk Factors and Improvements in Diagnosis |journal=Rev Diabet Stud |volume=12 |issue=1-2 |pages=110–8 |year=2015 |pmid=26676664 |doi=10.1900/RDS.2015.12.110 |url=}}</ref>
*[[Hypertension]]
*[[Dyslipidemia]]
*[[Smoking]]: [[smoking]] is associated with worsening renal function
*Inadequate glycemic control
===Non-modifiable Risk Factors===
Non-modifiable risk factors include:<ref name="pmid25342915">{{cite journal |vauthors=Lim AKh |title=Diabetic nephropathy - complications and treatment |journal=Int J Nephrol Renovasc Dis |volume=7 |issue= |pages=361–81 |year=2014 |pmid=25342915 |pmc=4206379 |doi=10.2147/IJNRD.S40172 |url=}}</ref><ref name="pmid26676664">{{cite journal |vauthors=Tziomalos K, Athyros VG |title=Diabetic Nephropathy: New Risk Factors and Improvements in Diagnosis |journal=Rev Diabet Stud |volume=12 |issue=1-2 |pages=110–8 |year=2015 |pmid=26676664 |doi=10.1900/RDS.2015.12.110 |url=}}</ref>
*Age: advancing age is a risk factor for diabetic nephropathy
*Race: African Americans, Native Americans and Hispanics are at higher risk of developing diabetic nephropathy
*Family history: patients with a family history of diabetic nephropathy are more likely to develop diabetic nephropathy themselves
*Genetic profile: genetic variants in ACE, ALR2, APOC1, APOE, EPO, eNOS, HSPG2, VEGF, FRMD3, CARS, UNC13B, CPVL/CHN2, and GREM1 have been implicated in the development of diabetic nephropathy
*[[Obesity]]: [[obesity]] and especially increased abdominal circumference are associated with higher incidence of diabetic nephropathy


==References==
==References==

Revision as of 16:29, 28 November 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]

Overview

Risk Factors

Risk factors of diabetic nephropathy can be subcategorized into modifiable and non-modifiable risk factors:

Modifiable Risk Factors

Modifiable risk factors include:[1][2]

Non-modifiable Risk Factors

Non-modifiable risk factors include:[1][2]

  • Age: advancing age is a risk factor for diabetic nephropathy
  • Race: African Americans, Native Americans and Hispanics are at higher risk of developing diabetic nephropathy
  • Family history: patients with a family history of diabetic nephropathy are more likely to develop diabetic nephropathy themselves
  • Genetic profile: genetic variants in ACE, ALR2, APOC1, APOE, EPO, eNOS, HSPG2, VEGF, FRMD3, CARS, UNC13B, CPVL/CHN2, and GREM1 have been implicated in the development of diabetic nephropathy
  • Obesity: obesity and especially increased abdominal circumference are associated with higher incidence of diabetic nephropathy

References

  1. 1.0 1.1 Lim A (2014). "Diabetic nephropathy - complications and treatment". Int J Nephrol Renovasc Dis. 7: 361–81. doi:10.2147/IJNRD.S40172. PMC 4206379. PMID 25342915. Vancouver style error: initials (help)
  2. 2.0 2.1 Tziomalos K, Athyros VG (2015). "Diabetic Nephropathy: New Risk Factors and Improvements in Diagnosis". Rev Diabet Stud. 12 (1–2): 110–8. doi:10.1900/RDS.2015.12.110. PMID 26676664.

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