Microscopic polyangiitis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]

Overview

Laboratory findings consistent with the diagnosis of Microscopic polyangiitis include, leukocytosis, elevated erythrocyte sedimentation rate, proteinuria, hematuria, red cell casts, elevated blood urea nitrogen, elevated serum creatinine, and anti-neutrophil cytoplasmic antibodies.

Laboratory Findings

Laboratory findings consistent with the diagnosis of Microscopic polyangiitis include, anti-neutrophil cytoplasmic antibody, elevated blood urea nitrogen, elevated serum creatinine, elevated erythrocyte sedimentation rate, proteinuria, hematuria, red cell casts and leukocytosis.

Blood Work-up

• Complete blood count
• Serum creatinine
• Blood urea nitrogen
• leukocytosis
• Anti-neutrophil cytoplasmic antibody test

Urianlysis

• Protienuria
• Hematuria
• Red cell casts

Biopsy

Biopsy of the involved skin, lung, renal, and nerve can be made to help establish a diagnosis of Microscopic polyangiitis.

• Skin biopsy is characterized by the presences of immunoglobulins and complement components.
• Renal biopsy is characterized as crescent formation with focal necrosis.
• Lung biopsy is characterized as alveolar capillaritis.
• Nerve biopsy is characterized by vascular necrosis of small and medium sized vessels.