Von Willebrand disease epidemiology and demographics: Difference between revisions
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===Prevalence=== | ===Prevalence=== | ||
The prevalence of von Willebrand’s disease is 0.6 to 1.3%.<ref name="pmid18315614">{{cite journal| author=Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL et al.| title=von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). | journal=Haemophilia | year= 2008 | volume= 14 | issue= 2 | pages= 171-232 | pmid=18315614 | doi=10.1111/j.1365-2516.2007.01643.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18315614 }} </ref><ref name="pmid3492222">{{cite journal| author=Rodeghiero F, Castaman G, Dini E| title=Epidemiological investigation of the prevalence of von Willebrand's disease. | journal=Blood | year= 1987 | volume= 69 | issue= 2 | pages= 454-9 | pmid=3492222 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3492222 }} </ref> | The prevalence of von Willebrand’s disease is 0.6 to 1.3%.<ref name="pmid18315614">{{cite journal| author=Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL et al.| title=von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). | journal=Haemophilia | year= 2008 | volume= 14 | issue= 2 | pages= 171-232 | pmid=18315614 | doi=10.1111/j.1365-2516.2007.01643.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18315614 }} </ref><ref name="pmid3492222">{{cite journal| author=Rodeghiero F, Castaman G, Dini E| title=Epidemiological investigation of the prevalence of von Willebrand's disease. | journal=Blood | year= 1987 | volume= 69 | issue= 2 | pages= 454-9 | pmid=3492222 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3492222 }} </ref> | ||
It is estimated that the referral prevalence of von Willebrand’s disease is approximately 1 case per 10,000 persons. | It is estimated that the referral prevalence of von Willebrand’s disease is approximately 1 case per 10,000 persons.<ref name="pmid10959685">{{cite journal| author=Sadler JE, Mannucci PM, Berntorp E, Bochkov N, Boulyjenkov V, Ginsburg D et al.| title=Impact, diagnosis and treatment of von Willebrand disease. | journal=Thromb Haemost | year= 2000 | volume= 84 | issue= 2 | pages= 160-74 | pmid=10959685 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10959685 }} </ref> | ||
The actual abnormality (which does not necessarily lead to disease) occurs in 0.9-3% of the population. | The actual abnormality (which does not necessarily lead to disease) occurs in 0.9-3% of the population. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Epidemiology and Demographics
Prevalence
The prevalence of von Willebrand’s disease is 0.6 to 1.3%.[1][2] It is estimated that the referral prevalence of von Willebrand’s disease is approximately 1 case per 10,000 persons.[3]
The actual abnormality (which does not necessarily lead to disease) occurs in 0.9-3% of the population.
Age
Gender
Although autosomal inheritance pattern of disease lead to an equal distribution of male patients and female patients, the disease has female predominance whose bleeding tendency shows during menstruation.
Race
There is no racial predilection to vWD however, it may be more severe or apparent in people with blood type O.[4]
References
- ↑ Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL; et al. (2008). "von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA)". Haemophilia. 14 (2): 171–232. doi:10.1111/j.1365-2516.2007.01643.x. PMID 18315614.
- ↑ Rodeghiero F, Castaman G, Dini E (1987). "Epidemiological investigation of the prevalence of von Willebrand's disease". Blood. 69 (2): 454–9. PMID 3492222.
- ↑ Sadler JE, Mannucci PM, Berntorp E, Bochkov N, Boulyjenkov V, Ginsburg D; et al. (2000). "Impact, diagnosis and treatment of von Willebrand disease". Thromb Haemost. 84 (2): 160–74. PMID 10959685.
- ↑ Gill JC, Endres-Brooks J, Bauer PJ, Marks WJ, Montgomery RR (1987). "The effect of ABO blood group on the diagnosis of von Willebrand disease". Blood. 69 (6): 1691–5. PMID 3495304.