Von Willebrand disease history and symptoms: Difference between revisions
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==Symptoms== | ==Symptoms== | ||
The | The symptoms of von Willebrand’s disease vary among patients, depending on the level of residual von Willebrand factor activity, the disease subtype, and to some extent, age and sex. | ||
===Children=== | |||
Children with von Willebrand’s disease most frequently present with symptoms of bruising and epistaxis.<ref name="pmid26375306">{{cite journal| author=Sanders YV, Fijnvandraat K, Boender J, Mauser-Bunschoten EP, van der Bom JG, de Meris J et al.| title=Bleeding spectrum in children with moderate or severe von Willebrand disease: Relevance of pediatric-specific bleeding. | journal=Am J Hematol | year= 2015 | volume= 90 | issue= 12 | pages= 1142-8 | pmid=26375306 | doi=10.1002/ajh.24195 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26375306 }} </ref> | |||
===Adults=== | |||
Adults patients with vWD mainly present with the following:<ref name="pmid22918553">{{cite journal| author=de Wee EM, Sanders YV, Mauser-Bunschoten EP, van der Bom JG, Degenaar-Dujardin ME, Eikenboom J et al.| title=Determinants of bleeding phenotype in adult patients with moderate or severe von Willebrand disease. | journal=Thromb Haemost | year= 2012 | volume= 108 | issue= 4 | pages= 683-92 | pmid=22918553 | doi=10.1160/TH12-04-0244 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22918553 }} </ref> | |||
*bleeding after surgery and trauma (The majority of patients (60 to 80%) | |||
*Mucosa-associated bleeding | *Mucosa-associated bleeding | ||
This usually may manifest in the form of the following: | This usually may manifest in the form of the following: | ||
*Easy bruising | *Easy bruising | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
History
Symptoms
The symptoms of von Willebrand’s disease vary among patients, depending on the level of residual von Willebrand factor activity, the disease subtype, and to some extent, age and sex.
Children
Children with von Willebrand’s disease most frequently present with symptoms of bruising and epistaxis.[1]
Adults
Adults patients with vWD mainly present with the following:[2]
- bleeding after surgery and trauma (The majority of patients (60 to 80%)
- Mucosa-associated bleeding
This usually may manifest in the form of the following:
- Easy bruising
- Nosebleeds
- Oral cavity bleeding
- Bleeding after dental extraction/surgery
- Heavy menstrual periods
- Postpartum hemorrhage.
- Severe internal or joint bleeding is rare (which only occurs in type 3 vWD).
To make a diagnosis, there is usually personal or family history of bleeding and laboratory evidence of defective von Willebrand factor, factor VIII, or both.
References
- ↑ Sanders YV, Fijnvandraat K, Boender J, Mauser-Bunschoten EP, van der Bom JG, de Meris J; et al. (2015). "Bleeding spectrum in children with moderate or severe von Willebrand disease: Relevance of pediatric-specific bleeding". Am J Hematol. 90 (12): 1142–8. doi:10.1002/ajh.24195. PMID 26375306.
- ↑ de Wee EM, Sanders YV, Mauser-Bunschoten EP, van der Bom JG, Degenaar-Dujardin ME, Eikenboom J; et al. (2012). "Determinants of bleeding phenotype in adult patients with moderate or severe von Willebrand disease". Thromb Haemost. 108 (4): 683–92. doi:10.1160/TH12-04-0244. PMID 22918553.