Primary sclerosing cholangitis pathophysiology: Difference between revisions
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*[[Inflammatory bowel disease]] ([[IBD]]): approximately 70-80% of patients with primary sclerosing cholangitis have [[IBD]] ([[Crohn's disease]] and [[ulcerative colitis]]).<ref name="pmid21351115">{{cite journal |vauthors=Molodecky NA, Kareemi H, Parab R, Barkema HW, Quan H, Myers RP, Kaplan GG |title=Incidence of primary sclerosing cholangitis: a systematic review and meta-analysis |journal=Hepatology |volume=53 |issue=5 |pages=1590–9 |year=2011 |pmid=21351115 |doi=10.1002/hep.24247 |url=}}</ref> | *[[Inflammatory bowel disease]] ([[IBD]]): approximately 70-80% of patients with primary sclerosing cholangitis have [[IBD]] ([[Crohn's disease]] and [[ulcerative colitis]]).<ref name="pmid21351115">{{cite journal |vauthors=Molodecky NA, Kareemi H, Parab R, Barkema HW, Quan H, Myers RP, Kaplan GG |title=Incidence of primary sclerosing cholangitis: a systematic review and meta-analysis |journal=Hepatology |volume=53 |issue=5 |pages=1590–9 |year=2011 |pmid=21351115 |doi=10.1002/hep.24247 |url=}}</ref> | ||
*[[Autoimmune hepatitis]]: approximately 35% of children with primary sclerosing cholangitis have associated [[autoimmune hepatitis]], while only 5% of adults have combined primary sclerosing cholangitis with associated [[autoimmune hepatitis]]. | *[[Autoimmune hepatitis]]: approximately 35% of children with primary sclerosing cholangitis have associated [[autoimmune hepatitis]], while only 5% of adults have combined primary sclerosing cholangitis with associated [[autoimmune hepatitis]]. | ||
*[[Gallbladder]] disease: this includes [[gallbladder]] stones, [[polyps]] and cancer. | *[[Gallbladder]] disease: this includes [[gallbladder]] stones and [[cholecystitis]], [[polyps]] and cancer.<ref name="pmid12014717">{{cite journal |vauthors=Buckles DC, Lindor KD, Larusso NF, Petrovic LM, Gores GJ |title=In primary sclerosing cholangitis, gallbladder polyps are frequently malignant |journal=Am. J. Gastroenterol. |volume=97 |issue=5 |pages=1138–42 |year=2002 |pmid=12014717 |doi=10.1111/j.1572-0241.2002.05677.x |url=}}</ref><ref name="pmid18222013">{{cite journal |vauthors=Said K, Glaumann H, Bergquist A |title=Gallbladder disease in patients with primary sclerosing cholangitis |journal=J. Hepatol. |volume=48 |issue=4 |pages=598–605 |year=2008 |pmid=18222013 |doi=10.1016/j.jhep.2007.11.019 |url=}}</ref> | ||
==References== | ==References== | ||
Revision as of 23:32, 8 December 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]
Overview
Pathophysiology
Gross Pathology
Microscopic Pathology
Genetics
Associated Conditions
Some of the conditions associated with primary sclerosing cholangitis include:[1]
- Inflammatory bowel disease (IBD): approximately 70-80% of patients with primary sclerosing cholangitis have IBD (Crohn's disease and ulcerative colitis).[2]
- Autoimmune hepatitis: approximately 35% of children with primary sclerosing cholangitis have associated autoimmune hepatitis, while only 5% of adults have combined primary sclerosing cholangitis with associated autoimmune hepatitis.
- Gallbladder disease: this includes gallbladder stones and cholecystitis, polyps and cancer.[3][4]
References
- ↑ Lazaridis KN, LaRusso NF (2016). "Primary Sclerosing Cholangitis". N. Engl. J. Med. 375 (12): 1161–70. doi:10.1056/NEJMra1506330. PMID 27653566.
- ↑ Molodecky NA, Kareemi H, Parab R, Barkema HW, Quan H, Myers RP, Kaplan GG (2011). "Incidence of primary sclerosing cholangitis: a systematic review and meta-analysis". Hepatology. 53 (5): 1590–9. doi:10.1002/hep.24247. PMID 21351115.
- ↑ Buckles DC, Lindor KD, Larusso NF, Petrovic LM, Gores GJ (2002). "In primary sclerosing cholangitis, gallbladder polyps are frequently malignant". Am. J. Gastroenterol. 97 (5): 1138–42. doi:10.1111/j.1572-0241.2002.05677.x. PMID 12014717.
- ↑ Said K, Glaumann H, Bergquist A (2008). "Gallbladder disease in patients with primary sclerosing cholangitis". J. Hepatol. 48 (4): 598–605. doi:10.1016/j.jhep.2007.11.019. PMID 18222013.