Primary sclerosing cholangitis pathophysiology: Difference between revisions
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Some of the conditions associated with primary sclerosing cholangitis include:<ref name="pmid27653566">{{cite journal |vauthors=Lazaridis KN, LaRusso NF |title=Primary Sclerosing Cholangitis |journal=N. Engl. J. Med. |volume=375 |issue=12 |pages=1161–70 |year=2016 |pmid=27653566 |doi=10.1056/NEJMra1506330 |url=}}</ref> | Some of the conditions associated with primary sclerosing cholangitis include:<ref name="pmid27653566">{{cite journal |vauthors=Lazaridis KN, LaRusso NF |title=Primary Sclerosing Cholangitis |journal=N. Engl. J. Med. |volume=375 |issue=12 |pages=1161–70 |year=2016 |pmid=27653566 |doi=10.1056/NEJMra1506330 |url=}}</ref> | ||
*[[Inflammatory bowel disease]] ([[IBD]]): approximately 70-80% of patients with primary sclerosing cholangitis have [[IBD]] ([[Crohn's disease]] and [[ulcerative colitis]]).<ref name="pmid21351115">{{cite journal |vauthors=Molodecky NA, Kareemi H, Parab R, Barkema HW, Quan H, Myers RP, Kaplan GG |title=Incidence of primary sclerosing cholangitis: a systematic review and meta-analysis |journal=Hepatology |volume=53 |issue=5 |pages=1590–9 |year=2011 |pmid=21351115 |doi=10.1002/hep.24247 |url=}}</ref> | *[[Inflammatory bowel disease]] ([[IBD]]): approximately 70-80% of patients with primary sclerosing cholangitis have [[IBD]] ([[Crohn's disease]] and [[ulcerative colitis]]).<ref name="pmid21351115">{{cite journal |vauthors=Molodecky NA, Kareemi H, Parab R, Barkema HW, Quan H, Myers RP, Kaplan GG |title=Incidence of primary sclerosing cholangitis: a systematic review and meta-analysis |journal=Hepatology |volume=53 |issue=5 |pages=1590–9 |year=2011 |pmid=21351115 |doi=10.1002/hep.24247 |url=}}</ref> | ||
*[[Autoimmune hepatitis]]: approximately 35% of children with primary sclerosing cholangitis have associated [[autoimmune hepatitis]], while only 5% of adults have combined primary sclerosing cholangitis with associated [[autoimmune hepatitis]].<ref name="pmid11059857">{{cite journal |vauthors=Kaya M, Angulo P, Lindor KD |title=Overlap of autoimmune hepatitis and primary sclerosing cholangitis: an evaluation of a modified scoring system |journal=J. Hepatol. |volume=33 |issue=4 |pages=537–42 |year=2000 |pmid=11059857 |doi= |url=}}</ref> | *[[Autoimmune hepatitis]]: approximately 35% of children with primary sclerosing cholangitis have associated [[autoimmune hepatitis]]<ref name="pmid12830004">{{cite journal |vauthors=Feldstein AE, Perrault J, El-Youssif M, Lindor KD, Freese DK, Angulo P |title=Primary sclerosing cholangitis in children: a long-term follow-up study |journal=Hepatology |volume=38 |issue=1 |pages=210–7 |year=2003 |pmid=12830004 |doi=10.1053/jhep.2003.50289 |url=}}</ref>, while only 5% of adults have combined primary sclerosing cholangitis with associated [[autoimmune hepatitis]].<ref name="pmid11059857">{{cite journal |vauthors=Kaya M, Angulo P, Lindor KD |title=Overlap of autoimmune hepatitis and primary sclerosing cholangitis: an evaluation of a modified scoring system |journal=J. Hepatol. |volume=33 |issue=4 |pages=537–42 |year=2000 |pmid=11059857 |doi= |url=}}</ref> | ||
*[[Gallbladder]] disease: this includes [[gallbladder]] stones and [[cholecystitis]], [[polyps]] and cancer.<ref name="pmid12014717">{{cite journal |vauthors=Buckles DC, Lindor KD, Larusso NF, Petrovic LM, Gores GJ |title=In primary sclerosing cholangitis, gallbladder polyps are frequently malignant |journal=Am. J. Gastroenterol. |volume=97 |issue=5 |pages=1138–42 |year=2002 |pmid=12014717 |doi=10.1111/j.1572-0241.2002.05677.x |url=}}</ref><ref name="pmid18222013">{{cite journal |vauthors=Said K, Glaumann H, Bergquist A |title=Gallbladder disease in patients with primary sclerosing cholangitis |journal=J. Hepatol. |volume=48 |issue=4 |pages=598–605 |year=2008 |pmid=18222013 |doi=10.1016/j.jhep.2007.11.019 |url=}}</ref> | *[[Gallbladder]] disease: this includes [[gallbladder]] stones and [[cholecystitis]], [[polyps]] and cancer.<ref name="pmid12014717">{{cite journal |vauthors=Buckles DC, Lindor KD, Larusso NF, Petrovic LM, Gores GJ |title=In primary sclerosing cholangitis, gallbladder polyps are frequently malignant |journal=Am. J. Gastroenterol. |volume=97 |issue=5 |pages=1138–42 |year=2002 |pmid=12014717 |doi=10.1111/j.1572-0241.2002.05677.x |url=}}</ref><ref name="pmid18222013">{{cite journal |vauthors=Said K, Glaumann H, Bergquist A |title=Gallbladder disease in patients with primary sclerosing cholangitis |journal=J. Hepatol. |volume=48 |issue=4 |pages=598–605 |year=2008 |pmid=18222013 |doi=10.1016/j.jhep.2007.11.019 |url=}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]
Overview
Pathophysiology
Gross Pathology
Microscopic Pathology
Genetics
Associated Conditions
Some of the conditions associated with primary sclerosing cholangitis include:[1]
- Inflammatory bowel disease (IBD): approximately 70-80% of patients with primary sclerosing cholangitis have IBD (Crohn's disease and ulcerative colitis).[2]
- Autoimmune hepatitis: approximately 35% of children with primary sclerosing cholangitis have associated autoimmune hepatitis[3], while only 5% of adults have combined primary sclerosing cholangitis with associated autoimmune hepatitis.[4]
- Gallbladder disease: this includes gallbladder stones and cholecystitis, polyps and cancer.[5][6]
References
- ↑ Lazaridis KN, LaRusso NF (2016). "Primary Sclerosing Cholangitis". N. Engl. J. Med. 375 (12): 1161–70. doi:10.1056/NEJMra1506330. PMID 27653566.
- ↑ Molodecky NA, Kareemi H, Parab R, Barkema HW, Quan H, Myers RP, Kaplan GG (2011). "Incidence of primary sclerosing cholangitis: a systematic review and meta-analysis". Hepatology. 53 (5): 1590–9. doi:10.1002/hep.24247. PMID 21351115.
- ↑ Feldstein AE, Perrault J, El-Youssif M, Lindor KD, Freese DK, Angulo P (2003). "Primary sclerosing cholangitis in children: a long-term follow-up study". Hepatology. 38 (1): 210–7. doi:10.1053/jhep.2003.50289. PMID 12830004.
- ↑ Kaya M, Angulo P, Lindor KD (2000). "Overlap of autoimmune hepatitis and primary sclerosing cholangitis: an evaluation of a modified scoring system". J. Hepatol. 33 (4): 537–42. PMID 11059857.
- ↑ Buckles DC, Lindor KD, Larusso NF, Petrovic LM, Gores GJ (2002). "In primary sclerosing cholangitis, gallbladder polyps are frequently malignant". Am. J. Gastroenterol. 97 (5): 1138–42. doi:10.1111/j.1572-0241.2002.05677.x. PMID 12014717.
- ↑ Said K, Glaumann H, Bergquist A (2008). "Gallbladder disease in patients with primary sclerosing cholangitis". J. Hepatol. 48 (4): 598–605. doi:10.1016/j.jhep.2007.11.019. PMID 18222013.