Primary sclerosing cholangitis laboratory findings

Primary sclerosing cholangitis Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]

Laboratory Findings

Liver Function Tests

Primary sclerosing cholangitis typically has a cholestatic clinical picture with elevation of ALP, and aminotransferases (AST and ALT) may be elevated to 2-3 times of the upper normal level. However, LFTs may be normal.

Immunoglobulins

• Hypergammaglobulinemia
• Elevated IgM levels
• Elevated IgG4 levels

Autoantibodies and Serology

One or more of the following autoantibodies may be present in patients with primary sclerosing cholangitis:

• Anti-neutrophil cytoplasmic antibody (p-ANCA)
• Anti-nuclear antibody (ANA)
• Anti-smooth muscle antibody (Anti-Sm)
• Anti-endothelial antibody
• Anti-cardiolipin antibody
• Thyroperoxidase
• Thyroglobulin
• Rheumatoid factor (RF)