Von Willebrand disease risk factors: Difference between revisions
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==Risk factors== | ==Risk factors== | ||
Interestingly the risks of cardiovascular disease and ischemic stroke are reduced among patients with von Willebrand’s disease.<ref name="pmid23506463">{{cite journal| author=Sanders YV, Eikenboom J, de Wee EM, van der Bom JG, Cnossen MH, Degenaar-Dujardin ME et al.| title=Reduced prevalence of arterial thrombosis in von Willebrand disease. | journal=J Thromb Haemost | year= 2013 | volume= 11 | issue= 5 | pages= 845-54 | pmid=23506463 | doi=10.1111/jth.12194 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23506463 }} </ref><ref name="pmid26368360">{{cite journal| author=Seaman CD, Yabes J, Comer DM, Ragni MV| title=Does deficiency of von Willebrand factor protect against cardiovascular disease? Analysis of a national discharge register. | journal=J Thromb Haemost | year= 2015 | volume= 13 | issue= 11 | pages= 1999-2003 | pmid=26368360 | doi=10.1111/jth.13142 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26368360 }} </ref> | Interestingly the risks of cardiovascular disease and ischemic stroke are reduced among patients with von Willebrand’s disease.<ref name="pmid23506463">{{cite journal| author=Sanders YV, Eikenboom J, de Wee EM, van der Bom JG, Cnossen MH, Degenaar-Dujardin ME et al.| title=Reduced prevalence of arterial thrombosis in von Willebrand disease. | journal=J Thromb Haemost | year= 2013 | volume= 11 | issue= 5 | pages= 845-54 | pmid=23506463 | doi=10.1111/jth.12194 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23506463 }} </ref><ref name="pmid26368360">{{cite journal| author=Seaman CD, Yabes J, Comer DM, Ragni MV| title=Does deficiency of von Willebrand factor protect against cardiovascular disease? Analysis of a national discharge register. | journal=J Thromb Haemost | year= 2015 | volume= 13 | issue= 11 | pages= 1999-2003 | pmid=26368360 | doi=10.1111/jth.13142 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26368360 }} </ref> | ||
The individual's [[ABO blood group system|ABO blood group]] can influence presentation and pathology of vWD. Those individuals with blood group O have a lower mean level than individuals with other blood groups. Unless ABO group–specific vWF:antigen reference ranges are used, normal group O individuals can be diagnosed as type I vWD, and some individuals of blood group AB with a genetic defect of vWF may have the diagnosis overlooked because vWF levels are elevated due to blood group.<ref>{{cite journal | last = Gill | first = JC | coauthors = Endres-Brooks J, Bauer PJ, Marks WJ, Montgomery RR | title = The effect of ABO blood group on the diagnosis of von Willebrand disease | journal = Blood | volume = 69 | issue = 6 | pages = 1691–5 | publisher = | date = 1987 | url = http://www.bloodjournal.org/cgi/content/abstract/69/6/1691 | doi = | pmid = 3495304 | accessdate = }}</ref> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Risk factors
Interestingly the risks of cardiovascular disease and ischemic stroke are reduced among patients with von Willebrand’s disease.[1][2]
The individual's ABO blood group can influence presentation and pathology of vWD. Those individuals with blood group O have a lower mean level than individuals with other blood groups. Unless ABO group–specific vWF:antigen reference ranges are used, normal group O individuals can be diagnosed as type I vWD, and some individuals of blood group AB with a genetic defect of vWF may have the diagnosis overlooked because vWF levels are elevated due to blood group.[3]
References
- ↑ Sanders YV, Eikenboom J, de Wee EM, van der Bom JG, Cnossen MH, Degenaar-Dujardin ME; et al. (2013). "Reduced prevalence of arterial thrombosis in von Willebrand disease". J Thromb Haemost. 11 (5): 845–54. doi:10.1111/jth.12194. PMID 23506463.
- ↑ Seaman CD, Yabes J, Comer DM, Ragni MV (2015). "Does deficiency of von Willebrand factor protect against cardiovascular disease? Analysis of a national discharge register". J Thromb Haemost. 13 (11): 1999–2003. doi:10.1111/jth.13142. PMID 26368360.
- ↑ Gill, JC (1987). "The effect of ABO blood group on the diagnosis of von Willebrand disease". Blood. 69 (6): 1691–5. PMID 3495304. Unknown parameter
|coauthors=ignored (help)