Pharyngitis pathophysiology: Difference between revisions
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=Overview= | =Overview= | ||
The pathogenesis of the sore throat due to pharyngitis is poorly understood.<ref name=":0">{{cite book | last = Ferri | first = Fred | title = Md consult/first consult 14-month subscription : combo retail pack | publisher = Elsevier Saunders | location = Place of publication not identified | year = 2005 | isbn = 9781416026075 }}</ref> | The pathogenesis of the sore throat due to pharyngitis is poorly understood.<ref name=":0">{{cite book | last = Ferri | first = Fred | title = Md consult/first consult 14-month subscription : combo retail pack | publisher = Elsevier Saunders | location = Place of publication not identified | year = 2005 | isbn = 9781416026075 }}</ref> | ||
The pharynx is often the first site of infection for many contagious diseases such as the common cold. This is because viruses and bacteria often settle in this part of the body after a person inhales dust or water vapor containing the microorganism. Infection can also arise when a person touches their nose or mouth after having touched an object shared with another person with the disease. The foreign invader reproduces rapidly after settling on the body tissue. Generally pharyngitis is a primary disease, but may be associated with systemic disorders such as the acute retroviral syndrome, or part of a more generalized upper respiratory tract infection | The pharynx is often the first site of infection for many contagious diseases such as the common cold. This is because viruses and bacteria often settle in this part of the body after a person inhales dust or water vapor containing the microorganism. Infection can also arise when a person touches their nose or mouth after having touched an object shared with another person with the disease. The foreign invader reproduces rapidly after settling on the body tissue. Generally pharyngitis is a primary disease, but may be associated with systemic disorders such as the acute retroviral syndrome, or part of a more generalized [[upper respiratory tract infection]].<ref>{{cite book | last = Bennett | first = John | title = Mandell, Douglas, and Bennett's principles and practice of infectious diseases | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2015 | isbn = 978-1455748013 }}</ref> | ||
== Pathophysiology == | == Pathophysiology == | ||
Revision as of 16:37, 23 December 2016
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Overview
The pathogenesis of the sore throat due to pharyngitis is poorly understood.[1] The pharynx is often the first site of infection for many contagious diseases such as the common cold. This is because viruses and bacteria often settle in this part of the body after a person inhales dust or water vapor containing the microorganism. Infection can also arise when a person touches their nose or mouth after having touched an object shared with another person with the disease. The foreign invader reproduces rapidly after settling on the body tissue. Generally pharyngitis is a primary disease, but may be associated with systemic disorders such as the acute retroviral syndrome, or part of a more generalized upper respiratory tract infection.[2]
Pathophysiology
The pathogenesis of the sore throat due to pharyngitis is poorly understood.[1] Rhinoviral infections produce bradykinin and lysylbradykinin, which are known inflammatory mediators that can excite nerve endings in the pharynx to cause pain.[3]
References
- ↑ 1.0 1.1 Ferri, Fred (2005). Md consult/first consult 14-month subscription : combo retail pack. Place of publication not identified: Elsevier Saunders. ISBN 9781416026075.
- ↑ Bennett, John (2015). Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1455748013.
- ↑ Proud D, Naclerio RM, Gwaltney JM, Hendley JO (1990) Kinins are generated in nasal secretions during natural rhinovirus colds. J Infect Dis 161 (1):120-3. PMID: 2295843