Von Willebrand disease epidemiology and demographics: Difference between revisions
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Prince Tano Djan, BSc, MBChB [2]
Overview
The prevalence of von Willebrand’s disease is 0.6 to 1.3%.[1][2] It is estimated that the referral prevalence of von Willebrand’s disease is approximately 1 case per 10,000 persons.[3] The actual abnormality (which does not necessarily lead to disease) occurs in 0.9-3% of the population. The symptoms of VWD is disproportionately more common in women of child-bearing age.[1] Although autosomal inheritance pattern of disease lead to an equal distribution of male patients and female patients, the disease has female predominance whose bleeding tendency shows during menstruation.[4][5] There is no racial predilection to vWD however, it may be more severe or apparent in people with blood type O.[6]
Epidemiology and Demographics
Prevalence
The prevalence of von Willebrand’s disease is 0.6 to 1.3%.[1][2] It is estimated that the referral prevalence of von Willebrand’s disease is approximately 1 case per 10,000 persons.[3]
The actual abnormality (which does not necessarily lead to disease) occurs in 0.9-3% of the population.
Age
The symptoms of VWD is disproportionately more common in women of child-bearing age.[1]
Gender
Although autosomal inheritance pattern of disease lead to an equal distribution of male patients and female patients, the disease has female predominance whose bleeding tendency shows during menstruation.[4][5]
Race
There is no racial predilection to vWD however, it may be more severe or apparent in people with blood type O.[6]
References
- ↑ 1.0 1.1 1.2 1.3 Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL; et al. (2008). "von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA)". Haemophilia. 14 (2): 171–232. doi:10.1111/j.1365-2516.2007.01643.x. PMID 18315614.
- ↑ 2.0 2.1 Rodeghiero F, Castaman G, Dini E (1987). "Epidemiological investigation of the prevalence of von Willebrand's disease". Blood. 69 (2): 454–9. PMID 3492222.
- ↑ 3.0 3.1 Sadler JE, Mannucci PM, Berntorp E, Bochkov N, Boulyjenkov V, Ginsburg D; et al. (2000). "Impact, diagnosis and treatment of von Willebrand disease". Thromb Haemost. 84 (2): 160–74. PMID 10959685.
- ↑ 4.0 4.1 Lee CA (1999). "Women and inherited bleeding disorders: menstrual issues". Semin Hematol. 36 (3 Suppl 4): 21–7. PMID 10513768.
- ↑ 5.0 5.1 Miller CH, Philipp CS, Stein SF, Kouides PA, Lukes AS, Heit JA; et al. (2011). "The spectrum of haemostatic characteristics of women with unexplained menorrhagia". Haemophilia. 17 (1): e223–9. doi:10.1111/j.1365-2516.2010.02382.x. PMID 21040234.
- ↑ 6.0 6.1 Gill JC, Endres-Brooks J, Bauer PJ, Marks WJ, Montgomery RR (1987). "The effect of ABO blood group on the diagnosis of von Willebrand disease". Blood. 69 (6): 1691–5. PMID 3495304.