Helicobacter pylori infection diagnostic test: Difference between revisions

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Revision as of 20:31, 16 January 2017

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Yamuna Kondapally, M.B.B.S [2]

Antibody testing is inexpensive and widely available but poor PPV in populations with a low prevalence of H. pylori infection limits its usefulness in clinical practice.
The UBTs and fecal antigen tests provide reliable means of identifying active H. pylori infection before antibiotic therapy.
The UBT is the most reliable nonendoscopic test to document eradication of H. pylori infection.
The monclonal fecal antigen test provides another nonendoscopic means of establishing H. pylori cure after antibiotic treatment.
Testing to prove H. pylori eradication appears to be most accurate if performed at least 4 wk after the completion of antibiotic therapy.

The nonendoscopic diagnostic testing methods for H.pylori include:

Antibody testing depends on the detection of H.pylori specific IgG antibodies in serum, whole blood, or urine.^[1]
The IgG antibodies typically become detected 21 days after infection and can remain present long after eradication.
Antibodies are detected using enzyme-linked immunosorbent assay (ELISA) and latex agglutination techniques.

The urea labeled with either the nonradioactive isotope 13C or the radioactive isotope 14C is ingested.
The H.pylori urease converts urea to labeled CO2, which can be quantitated in expired breath.

@@ Line 36: / Line 36: @@
 ===Urea Breath Tests===
+*Urea breath test identifies active H.pylori infection.<ref name="pmid15569102">{{cite journal| author=Gisbert JP, Pajares JM| title=Review article: 13C-urea breath test in the diagnosis of Helicobacter pylori infection -- a critical review. | journal=Aliment Pharmacol Ther | year= 2004 | volume= 20 | issue= 10 | pages= 1001-17 | pmid=15569102 | doi=10.1111/j.1365-2036.2004.02203.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15569102  }} </ref>
+*'''Method'''
+:*The urea labeled with either the nonradioactive isotope 13C or the radioactive isotope 14C is ingested.
+:*The H.pylori urease converts urea to labeled CO2, which can be quantitated in expired breath.
+*13C labeled urea is preferred in children and pregnant females.
+*Urea breath test has 95% sensitivity and specificity
 ==References==
 {{Reflist|2}}