Helicobacter pylori infection diagnostic test: Difference between revisions
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*As this test mainly depends on urease activity of H.pylori, the sensitivity of test is decreased by medications such as bismuth containing products, PPIs and antibiotics as they reduce organism density or urease activity. It is recommended to with hold PPIs for 7-14 days prior to test, and bismuth and antibiotics are withheld for at least 28days. | *As this test mainly depends on urease activity of H.pylori, the sensitivity of test is decreased by medications such as bismuth containing products, PPIs and antibiotics as they reduce organism density or urease activity. It is recommended to with hold PPIs for 7-14 days prior to test, and bismuth and antibiotics are withheld for at least 28days. | ||
*Antacids do not affect the efficacy of the test. | *Antacids do not affect the efficacy of the test. | ||
===Fecal Antigen Test=== | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} |
Revision as of 13:20, 17 January 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Yamuna Kondapally, M.B.B.S[2]
Overview
Nonendoscpic diagnostic studies
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The nonendoscopic diagnostic testing methods for H.pylori include:
- Antibody tests
- Urea breath test
- Fecal antigen test
Antibody tests
- Antibody testing depends on the detection of H.pylori specific IgG antibodies in serum, whole blood, or urine.[1]
- The IgG antibodies typically become detected 21 days after infection and can remain present long after eradication.
- Antibodies are detected using enzyme-linked immunosorbent assay (ELISA) and latex agglutination techniques.
Urea Breath Tests
- Urea breath test identifies active H.pylori infection.[2]
- Procedure
- The urea labeled with either the nonradioactive isotope 13C or the radioactive isotope 14C is ingested.
- The H.pylori urease converts labeled urea to CO2, which can be quantitated in expired breath.
- 13C labeled urea is preferred in children and pregnant females.
- Urea breath test has 95% sensitivity and specificity.
- This test is an accurate means of post-treatment testing.
- As this test mainly depends on urease activity of H.pylori, the sensitivity of test is decreased by medications such as bismuth containing products, PPIs and antibiotics as they reduce organism density or urease activity. It is recommended to with hold PPIs for 7-14 days prior to test, and bismuth and antibiotics are withheld for at least 28days.
- Antacids do not affect the efficacy of the test.
Fecal Antigen Test
References
- ↑ Ho B, Marshall BJ (2000). "Accurate diagnosis of Helicobacter pylori. Serologic testing". Gastroenterol Clin North Am. 29 (4): 853–62. PMID 11190069.
- ↑ Gisbert JP, Pajares JM (2004). "Review article: 13C-urea breath test in the diagnosis of Helicobacter pylori infection -- a critical review". Aliment Pharmacol Ther. 20 (10): 1001–17. doi:10.1111/j.1365-2036.2004.02203.x. PMID 15569102.