Tropical sprue differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Tropical sprue must be differentiated from celiac disease, chronic diarrhea, Clonorchiasis, traveler's diarrhea, and whipworm.

Differentiating Tropical sprue from other Diseases

Chronic diarrhea

• Tropical sprue
• Ulcerative Colitis,
• Crohn's disease
• Diarrhea, chronic responsive to antiparasitic drugs
• Diarrhea, chronic unknown
• Inflammatory bowel disease, new onset post-travel (Crohn or ulcerative colitis)
• Irritable bowel syndrome
• Irritable bowel syndrome, post infectious
• Lactose intolerance, post infectious
• Malabsorption

Acute diarrhea

• E. coli
• Clostridium difficile-associated disease
• Campylobacter
• Cholera (toxigenic Vibrio cholerae)
• Cryptosporidium
• Cyclospora
• Diarrhea, acute bacterial
• Diarrhea, acute parasitic
• Diarrhea, acute unspecified
• Diarrhea, acute viral
• Dysentery, acute unspecified
• Entamoeba histolytica, ameba
• E. histolytica, diarrhea
• E. histolytica, dysentery
• Food poisoning
• Gastroenteritis
• Giardia
• Isospora
• Noncholera Vibrio
• Salmonella, other
• Shiga toxin-producing Escherichia coli
• Shigella, S. boydii
• Shigella, S. dysenteriae
• Shigella, S. flexneri

The following diseases have a similar presentation to tropical sprue.

• Celiac Disease
• Chronic diarrhea
• Clonorchiasis
• Traveler's diarrhea
• Whipworm