Blastomycosis differential diagnosis: Difference between revisions
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!Differentiating Laboratory findings | !Differentiating Laboratory findings | ||
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|Histoplasmosis | |[[Histoplasmosis]] | ||
|Palate and oral ulcers with spleenomegaly | |Palate and oral ulcers with spleenomegaly | ||
|Culture findings : yeast are typically smaller, with narrow-based budding, found intracellularly within macrophages | |Culture findings : yeast are typically smaller, with narrow-based budding, found intracellularly within macrophages | ||
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Urine antigen testing | Urine antigen testing | ||
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|Coccidioidomycosis | |[[Coccidioidomycosis]] | ||
|Endemic to southwestern US region | |Endemic to southwestern US region | ||
|Characteristic spherule appearance on culture media . | |Characteristic spherule appearance on culture media . | ||
Serologic tests( enzyme immune assay )more sensitive | Serologic tests( enzyme immune assay )more sensitive | ||
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|Paracoccidioidomycosis | |[[Paracoccidioidomycosis]] | ||
|Lymphadenopathy, | |Lymphadenopathy, | ||
Hepatosplenomegaly, | Hepatosplenomegaly, | ||
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|Culture findings smaller fungi with thin cell walls, forming mariner wheel appearance, circumferentially surrounding the parent cell. | |Culture findings smaller fungi with thin cell walls, forming mariner wheel appearance, circumferentially surrounding the parent cell. | ||
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|Sporotrichosis | |[[Sporotrichosis]] | ||
|Gardeners are at high risk | |Gardeners are at high risk | ||
Lymphadenitis (nodular, and subacute to chronic) | Lymphadenitis (nodular, and subacute to chronic) | ||
|Biopsy of the skin confirms the diagnosis | |Biopsy of the skin confirms the diagnosis | ||
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|Pulmonary Tuberculosis | |[[Tuberculosis|Pulmonary Tuberculosis]] | ||
|No cutaneous involvement | |No cutaneous involvement | ||
|Sputum positive for acid fast bacteria | |Sputum positive for acid fast bacteria | ||
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| | |[[Nocardiosis]] | ||
|Immunocompromised people | |Immunocompromised people | ||
worldwide distribution | worldwide distribution | ||
Revision as of 19:23, 24 February 2017
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Blastomycosis Microchapters |
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Blastomycosis differential diagnosis On the Web |
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American Roentgen Ray Society Images of Blastomycosis differential diagnosis |
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Risk calculators and risk factors for Blastomycosis differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Vidit Bhargava, M.B.B.S [2] Aditya Ganti M.B.B.S. [3]
Overview
Acute pneumonia itself is a mild flu-like illness that needs to be differentiated from a number of other fungal/bacterial disorders. These disorders have overlapping signs & symptoms that often need detailed History, Physical examination and serological tests to pin-point the diagnosis. It can be often misinterpreted as community acquired pneumonia.
Fungal
Bacterial
- Anthrax
- Legionella
- Listeriosis
- Brucellosis
- Tuberculosis
- Scrub typhus
- Leptospirosis
- Cat scratch fever
Viral
- Chickenpox
- Herpes(Prodrome)
- Influenza
- Parainfluenza
- HIV -1/-2
- Coxsackie B virus
- Hepatits
- Cytomegalovirus
- Eastern equine encephalitis virus
- Venezuelan equine encephalitis
- Coronavirus
- California Encephalitis virus
Chronic and disseminated disease
Chronic blastomycosis may be initially confused with a malignancy or tuberculosis. While spread to other areas may be confused with malignancy as well. Skin lesions are often misdiagnosed as pyoderma gangreosum or keratoacanthoma. Therefore, a high index of suspicion is needed on the part of physician to diagnose blastomycosis
| Disease | Differentiating Features | Differentiating Laboratory findings |
|---|---|---|
| Histoplasmosis | Palate and oral ulcers with spleenomegaly | Culture findings : yeast are typically smaller, with narrow-based budding, found intracellularly within macrophages
Pancytopenia Urine antigen testing |
| Coccidioidomycosis | Endemic to southwestern US region | Characteristic spherule appearance on culture media .
Serologic tests( enzyme immune assay )more sensitive |
| Paracoccidioidomycosis | Lymphadenopathy,
Hepatosplenomegaly, Bone marrow dysfunction Endemic to central and south america |
Culture findings smaller fungi with thin cell walls, forming mariner wheel appearance, circumferentially surrounding the parent cell. |
| Sporotrichosis | Gardeners are at high risk
Lymphadenitis (nodular, and subacute to chronic) |
Biopsy of the skin confirms the diagnosis |
| Pulmonary Tuberculosis | No cutaneous involvement | Sputum positive for acid fast bacteria |
| Nocardiosis | Immunocompromised people
worldwide distribution |
Microscopic examination ; thin, branching gram-positive bacilli
acid fast positive |