Microscopic polyangiitis natural history, complications and prognosis: Difference between revisions
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According to the Five-Factor Score, a score of 0, 1, or greater than 2 has the following mortality rate | According to the Five-Factor Score, a score of 0, 1, or greater than 2 has the following mortality rate | ||
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<sup>[[Churg-Strauss syndrome natural history, complications and prognosis|[3]]]</sup> It has also been concluded that age greater than 65 is also a risk factor for mortality.<sup>[[Churg-Strauss syndrome natural history, complications and prognosis|[4]]]</sup> | <sup>[[Churg-Strauss syndrome natural history, complications and prognosis|[3]]]</sup> It has also been concluded that age greater than 65 is also a risk factor for mortality.<sup>[[Churg-Strauss syndrome natural history, complications and prognosis|[4]]]</sup> | ||
==References== | ==References== | ||
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Revision as of 19:08, 10 March 2017
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Microscopic polyangiitis Microchapters |
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Differentiating Microscopic polyangiitis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2];Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]
Overview
If left untreated, Microscopic polyangiitis can progress to end stage renal failure and respiratory failure. Complications of Microscopic polyangiitis include, alveolar hemorrhage, end stage renal failure, osteoarticular disease, and infections. The prognosis of Microscopic polyangiitis
Natural History
If left untreated, Microscopic polyangiitis can progress to end stage renal disease and respiratory failure.
Complications
Possible complications of Microscopic polyangiitis include:
- abdominal sepsis
- meningoencephalititis
- alveolar hemorrhage
- osteoarticular disease
- end stage renal failure
Prognosis
In the past the prognosis of Microscopic polyangiitis was fatal. Patients with Microscopic polyangiitis that was untreated had a mortality rate of about 90% in 2 years. With the advent of medications such as glucocorticoids and cyclophosphamide the mortality rate has decreased to a rate of 12 to 44 percent in about 4 to 10 years.[1]
The following are favorable prognostic factors:
- Aggressive treatment with immunosuppressants together with a corticosteriod.
- Renal-pulmonary syndrome is not present.
The following are poor prognostic factors:
| Five-Factor Score Assessment |
|---|
| Proteinuria > 1g/d |
| Creatinine > 140mm/l |
| Cardiomyopathy |
| Severe GI manifestations |
| CNS involvement |
According to the Five-Factor Score, a score of 0, 1, or greater than 2 has the following mortality rate
| Five-Factor Score | |
|---|---|
| Score | Mortality Rate |
| 0 | 12% |
| 1 | 26% |
| >2 | 46% |
[3] It has also been concluded that age greater than 65 is also a risk factor for mortality.[4]
References
- ↑ Corral-Gudino L, Borao-Cengotita-Bengoa M, Del Pino-Montes J, Lerma-Márquez JL (2011). "Overall survival, renal survival and relapse in patients with microscopic polyangiitis: a systematic review of current evidence". Rheumatology (Oxford). 50 (8): 1414–23. doi:10.1093/rheumatology/ker112. PMID 21406467.