Typhus pathophysiology: Difference between revisions
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*Scratching a louse-bite site allows the rickettsia-laden excrement to be inoculated into the bite wound. | *Scratching a louse-bite site allows the rickettsia-laden excrement to be inoculated into the bite wound. | ||
*Following transmission, rickettsia are ingested by [[macrophages]] and [[Polymorphonuclear cells|polymorphonuclea]]<nowiki/>r cells. On ingestion, they replicate intracellularly inside the lysed cells and disseminate systemically. | *Following transmission, rickettsia are ingested by [[macrophages]] and [[Polymorphonuclear cells|polymorphonuclea]]<nowiki/>r cells. On ingestion, they replicate intracellularly inside the lysed cells and disseminate systemically. | ||
===Incubation=== | |||
Incubation period of Typhus fever varies from one to two weeks. | |||
==References== | ==References== | ||
Revision as of 14:54, 27 March 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathophysiology
Transmission
- Rickettsial agents are usually not transmissible directly from person to person except by blood transfusion or organ transplantation, although sexual and placental transmission has been proposed for Coxiella.
- Transmission generally occurs via an infected arthropod vector or through exposure to an infected animal reservoir host.
| Type of Infection | Spread |
| Epidemic typhus | Body louse |
| Trench fever | Body louse |
| Murine typhus | Flea infested rats |
| Cat flea rickettsioses | Flea infested dogs and cats |
| Scrub typhus | Mites |
| Tick borne rickettsiosis | Ticks |
| Rickettsialpox | Mites |
| Anaplasmosis | Ixodes tick |
| Ehrlichiosis | Lone star tick |
| Q fever | Infected veterinary animals |
| Cat scratch disease | Infected cats |
| Oroya fever | Sandflies |
Dissemination
- Scratching a louse-bite site allows the rickettsia-laden excrement to be inoculated into the bite wound.
- Following transmission, rickettsia are ingested by macrophages and polymorphonuclear cells. On ingestion, they replicate intracellularly inside the lysed cells and disseminate systemically.
Incubation
Incubation period of Typhus fever varies from one to two weeks.
References