Rubella laboratory findings: Difference between revisions

	Rubella Microchapters
Home
Patient Information
Overview
Historical Perspective
Pathophysiology
Causes
Differentiating Rubella from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Treatment
Medical Therapy
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Case Studies
Case #1
Rubella laboratory findings On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Rubella laboratory findings All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Rubella laboratory findings
CDC on Rubella laboratory findings
Rubella laboratory findings in the news
Blogs on Rubella laboratory findings
Directions to Hospitals Treating Rubella
Risk calculators and risk factors for Rubella laboratory findings

Revision as of 16:39, 25 April 2017

Detection of specific IgM antibodies in a serum sample collected within the first few days after rash onset can provide presumptive evidence of a current or recent rubella virus infection
The optimum time-point for collection of serum is five days after the onset of symptoms (fever and rash) when >90% of cases will be IgM positive. Therefore, if serum collected less than five days after onset is negative, a second sample would be necessary to confirm/rule out rubella.

The measurement of rubella IgG antibody avidity can be used to distinguish between recent infection and remote rubella infection.
These avidity differences can be detected by using protein denaturants such as diethylamine (DEA) in the washing step of an enzyme-linked immunoassay (EIA) for rubella IgG.
In acute rubella virus infections, specific, low-avidity IgG lasts for up to three months after appearance of the IgG response.
The presence of high avidity antibodies, which develop by about three months after infection, provides evidence of remote infection

@@ Line 2: / Line 2: @@
 {{Rubella}}
-Please help WikiDoc by adding content here.  It's easy!  Click  [[Help:How_to_Edit_a_Page|here]]  to learn about editing.
+==Overview==
+==Laboratory Findings==
+===Serologic Testing===
+*Detection of specific IgM antibodies in a serum sample collected within the first few days after rash onset can provide presumptive evidence of a current or recent rubella virus infection
+*The optimum time-point for collection of serum is five days after the onset of symptoms (fever and rash) when >90% of cases will be IgM positive. Therefore, if serum collected less than five days after onset is negative, a second sample would be necessary to confirm/rule out rubella.
+====IgG Avidity Testing===
+*The measurement of rubella IgG antibody avidity can be used to distinguish between recent infection and remote rubella infection.
+*These avidity differences can be detected by using protein denaturants such as diethylamine (DEA) in the washing step of an enzyme-linked immunoassay (EIA) for rubella IgG.
+*In acute rubella virus infections, specific, low-avidity IgG lasts for up to three months after appearance of the IgG response.
+*The presence of high avidity antibodies, which develop by about three months after infection, provides evidence of remote infection
 ==References==
 {{Reflist|2}}