Histoplasmosis natural history, complications and prognosis: Difference between revisions
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===Prognosis=== | ===Prognosis=== | ||
Immunocompetent patients have excellent prognosis with symptoms resolving in 2 to 3 weeks. However, immunocompromised patients can have extensive spread of the infection and have poor prognosis. Mortality is high in HIV-infected persons who develop disseminated histoplasmosis. | Immunocompetent patients have excellent prognosis with symptoms resolving in 2 to 3 weeks. However, immunocompromised patients can have extensive spread of the infection and have poor prognosis. Mortality is high in HIV-infected persons who develop disseminated histoplasmosis. | ||
==References== | ==References== | ||
Revision as of 17:10, 4 May 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Natural history, complications and prognosis
Natural history
The incubation period of histoplasmosis is typically 3–17 days for the acute disease. If left untreated immunocompromised patients can have complications such as pericarditis, broncholithiasis, pulmonary nodules, mediastinal granuloma, or mediastinal fibrosis. In persons who develop progressive, chronic, or disseminated disease, symptoms may persist for months or longer. Most people spontaneously recover 2–3 weeks after onset of symptoms, although fatigue may persist longer.
Complications
Some of the complications observed among patients with acute or chronic histoplamosis include:[1]
- Fibrosing mediastinitis
- Mediastinal granuloma
- Calcified lymph nodes
- Adrenal hyperplasia
- Macular degeneration (ocular histoplasmosis)
- Pericarditis
- Broncholithiasis
- Pulmonary nodules
- Disseminated histoplasmosis
Prognosis
Immunocompetent patients have excellent prognosis with symptoms resolving in 2 to 3 weeks. However, immunocompromised patients can have extensive spread of the infection and have poor prognosis. Mortality is high in HIV-infected persons who develop disseminated histoplasmosis.
References
- ↑ Information for Healthcare Professionals about Histoplasmosis. Centers for Disease Control and Prevention. 2015. Available at: http://www.cdc.gov/fungal/diseases/histoplasmosis/health-professionals.html. Accessed February 2, 2016.